Effect of add-on aliskiren to type 1 angiotensin receptor blocker therapy on endothelial function and autonomic nervous system in hypertensive patients with ischemic heart disease.
Effect of add-on aliskiren to type 1 angiotensin receptor blocker therapy on endothelial function and autonomic nervous system in hypertensive patients with ischemic heart disease.
复制标题
阿利吉仑联合 1 型血管紧张素受体阻滞剂治疗对高血压伴缺血性心脏病患者内皮功能和自主神经系统的影响。
DOI：
10.1111/jch.12366
复制
发表时间：
2014
期刊：
影响因子：
2.8
通讯作者：
Nagai R
中科院分区：
文献类型：
--
作者：
Ozeki A;Amiya E;Watanabe M;Hosoya Y;Takata M;Watanabe A;Kawarasaki S;Nakao T;Watanabe S;Omori K;Yamada N;Tahara Y;Hirata Y;Nagai R
本研究的目的是评估阿利基伦对缬沙坦对高血压合并缺血性心脏病（IHD）患者内皮依赖性血管舒张的附加效应。用80mg缬沙坦治疗4周后，28名患者被分配到继续用缬沙坦治疗或加用缬沙坦加150mg阿利基伦治疗。Aliskiren显著降低血浆肾素活性，而通过血流介导的舒张（FMD）测量的内皮依赖性血管舒张没有改变。相比之下，aliskiren组的心率显著降低（基线和24周时分别为73.1±9.8至66.3±7.0次/分钟，[P = 0.009]）， R - R间隔的标准偏差（SDNN）显著增加。缬沙坦治疗加用阿利克伦可能不能改善内皮功能，尽管它通过调节高血压合并IHD患者的自主神经系统显著降低静息心率。
The aim of this study was to evaluate the add‐on effect of aliskiren to valsartan on endothelial‐dependent vasodilation in hypertensive patients with ischemic heart disease (IHD). After 4 weeks of treatment with 80 mg of valsartan, 28 patients were allocated to either continued treatment with valsartan or an add‐on treatment with valsartan plus 150 mg of aliskiren. Aliskiren significantly decreased plasma renin activity, whereas endothelium‐dependent vasodilation measured by flow‐mediated dilation (FMD) did not change. In contrast, heart rate significantly decreased (73.1 ± 9.8 to 66.3 ± 7.0 beats per minute at baseline and 24 weeks, respectively [P = .009]) and the standard deviation of the R‐R intervals (SDNN) significantly increased in the aliskiren group. The add‐on aliskiren to valsartan therapy may not improve endothelial functions, although it significantly reduced resting heart rate via regulation of the autonomic nervous system in hypertensive patients with IHD.