Aspirin inhibits hepatitis C virus entry by downregulating claudin‐1
Aspirin inhibits hepatitis C virus entry by downregulating claudin‐1
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DOI：
10.1111/jvh.12446
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发表时间：
2016-01
影响因子：
2.5
通讯作者：
P. Yin;L. Zhang
中科院分区：
文献类型：
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作者：
P. Yin;L. Zhang
阿司匹林以前曾被报道抑制丙型肝炎病毒（HCV）的复制。本研究的目的是调查阿司匹林是否参与阻断HCV进入。我们发现阿司匹林抑制HCVpp和感染性HCV的进入。Claudin-1（一种HCV受体）的水平被阿司匹林降低。我们的研究结果将阿司匹林的抗HCV作用扩展到HCV进入步骤，并进一步加强了阿司匹林的抗HCV作用。
Aspirin has previously been reported to inhibit hepatitis C virus (HCV) replication. The aim of this study was to investigate whether aspirin is involved in blocking HCV entry. We found that aspirin inhibits the entry of HCVpp and infectious HCV. The level of claudin‐1, an HCV receptor, is reduced by aspirin. Our results extend the anti‐HCV effect of aspirin to the HCV entry step and further reinforce the anti‐HCV role of aspirin.