Effectiveness and limitations of β-blocker therapy in congenital long-QT syndrome
Effectiveness and limitations of β-blocker therapy in congenital long-QT syndrome
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DOI：
10.1161/01.cir.101.6.616
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发表时间：
2000-02-15
期刊：
影响因子：
37.8
通讯作者：
Andrews, ML
中科院分区：
文献类型：
--
作者：
Moss, AJ;Zareba, W;Andrews, ML
背景：-受体阻滞剂是先天性长qt综合征（LQTS）的常规处方，但-受体阻滞剂在这种疾病中的有效性和局限性尚未得到评估。方法和结果：研究人群包括869名接受-受体阻滞剂治疗的LQTS患者。在开始-受体阻滞剂治疗前后的匹配时期分析-受体阻滞剂的有效性，并通过生存方法确定处方-受体阻滞剂治疗时与心脏事件相关的因素。在开始使用受体阻滞剂后，有显著的(P
Background-beta-blockers are routinely prescribed in congenital long-QT syndrome (LQTS), but the effectiveness and limitations of beta-blockers in this disorder have not been evaluated,Methods and Results-The study population comprised 869 LQTS patients treated with beta-blockers. Effectiveness of beta-blockers was analyzed during matched periods before and after starting beta-blocker therapy, and by survivorship methods to determine factors associated with cardiac events while on prescribed beta-blockers. After initiation of beta-blockers, there was a significant (P