Involvement of a metalloprotease in the shedding of human neutrophil Fc gamma RIIIB
Involvement of a metalloprotease in the shedding of human neutrophil Fc gamma RIIIB
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DOI：
10.1016/s0014-5793(97)00959-9
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发表时间：
1997-09-01
期刊：
影响因子：
3.5
通讯作者：
Verhoeven, AJ
中科院分区：
文献类型：
--
作者：
Middelhoven, PJ;Ager, A;Verhoeven, AJ
Fc gamma IIIb is a glycosylphosphatidylinositol(GPI)-anchored, low-affinity IgG receptor, expressed exclusively on human neutrophils, Upon activation or apoptosis of neutrophils, Fc gamma RIIIb is shed front the cell surface, but the enzyme(s) responsible for this process is (are) still unknown. Recently, metalloproteases have been suggested to mediate the shedding of cell surface proteins such as L-selectin and TNF-alpha. Using hydroxamic acid-based inhibitors of this class of proteases (BB-3103, Ro31-9790), we have observed a clear inhibitory effect on Fc gamma IIIb shedding after PMA stimulation of neutrophils or induction of apoptosis. These inhibitors did not affect PMA-induced degranulation or superoxide generation. (C) 1997 Federation of European Biochemical Societies.
