Water-Dispersible Ferrimagnetic Iron Oxide Nanocubes with Extremely High r2 Relaxivity for Highly Sensitive in Vivo MRI of Tumors
Water-Dispersible Ferrimagnetic Iron Oxide Nanocubes with Extremely High r2 Relaxivity for Highly Sensitive in Vivo MRI of Tumors
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DOI：
10.1021/nl3010308
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发表时间：
2012-06-01
期刊：
影响因子：
10.8
通讯作者：
Hyeon, Taeghwan
中科院分区：
文献类型：
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作者：
Lee, Nohyun;Choi, Yoonseok;Hyeon, Taeghwan
通过优化亚铁磁性氧化铁纳米立方体的总体尺寸，实现了理论预测的氧化铁纳米颗粒的最大r（2）弛豫率。均匀尺寸的氧化铁纳米立方体的边长为22 nm，与PEG-磷脂（WFION）封装，在水介质中表现出高的胶体稳定性。此外，WFION是生物相容的，并且在高达0.75 mg Fe/ml的浓度下不影响细胞活力。由于增强的胶体稳定性和高的r（2）弛豫率（761 mM（-1）s（-1）），使用临床3 T MR扫描仪，通过静脉注射22 nm大小的WFIONs，可以成功地进行肿瘤的体内MR成像。
The theoretically predicted maximum r(2) relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r(2) relaxivity (761 mM(-1) s(-1)), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner.