The subthalamic nucleus is one of multiple innervation sites for long-range corticofugal axons: a single-axon tracing study in the rat.
The subthalamic nucleus is one of multiple innervation sites for long-range corticofugal axons: a single-axon tracing study in the rat.
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DOI：
10.1523/jneurosci.5717-11.2012
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发表时间：
2012-04-25
期刊：
影响因子：
--
通讯作者：
Kita H
中科院分区：
文献类型：
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作者：
Kita T;Kita H
额叶皮层向丘脑下核（STN）提供强烈的兴奋输入，这些皮质-STN输入在控制基底神经节活动中起关键作用。解剖学和生理学研究认为，STN主要受源自额叶皮层深层V神经元的厚且传导快的锥体束轴突侧枝的支配，这意味着STN直接接受运动命令的传出拷贝。为了更仔细地检验这一假设，我们在大鼠身上进行了生物素化葡聚糖胺顺行追踪研究，以检查皮层起源层、亲本轴突的大小，以及皮层轴突是否向STN以外的大脑区域发射任何其他侧枝。本研究发现，皮质- stn投射主要是由一小部分小到中等大小的远端皮质轴突的侧支形成的，这些侧支也能支配其他多个脑部位，包括纹状体、丘脑联合核、上丘、交错带、脑桥核、其他多个脑干区域和脊髓。结果表明，某些V层神经元通过多个脑神经支配部位参与运动的联合控制，而皮质- stn投射是这个多皮质-神经系统的一部分。
The frontal cortex provides strong excitatory inputs to the subthalamic nucleus (STN), and these cortico-STN inputs play critical roles in the control of basal ganglia activity. It has been assumed from anatomical and physiological studies that STN is innervated mainly by collaterals of thick and fast conducting pyramidal tract axons originating from the frontal cortex deep layer V neurons, implying that STN directly receives efferent copies of motor commands. To more closely examine this assumption, we performed biotinylated dextran amine anterograde tracing studies in rats to examine the cortical layer of origin, the size of parent axons, and whether or not the cortical axons emit any other collaterals to brain areas other than STN. This study revealed that the cortico-STN projection is formed mostly by collaterals of a small fraction of small to medium sized long-range cortico-fugal axons, which also emit collaterals that innervate multiple other brain sites including the striatum, associative thalamic nuclei, superior colliculus, zona incerta, pontine nucleus, multiple other brainstem areas, and the spinal cord. The results imply that some layer V neurons are involved in associative control of movement through multiple brain innervation sites and that the cortico-STN projection is one part of this multiple cortico-fugal system.