Luteolin, a flavonoid with potential for cancer prevention and therapy.
Luteolin, a flavonoid with potential for cancer prevention and therapy.
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DOI：
10.2174/156800908786241050
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发表时间：
2008-11
影响因子：
3
通讯作者：
Shen HM
中科院分区：
文献类型：
--
作者：
Lin Y;Shi R;Wang X;Shen HM
木犀草素（Luteolin），又称3′，4 ′，5，7-四羟基黄酮，是一种常见的黄酮类化合物，广泛存在于水果、蔬菜和中草药中。富含木犀草素的植物已被用于治疗各种疾病，如高血压，炎症性疾病和癌症的中国传统医学。毛地黄黄酮具有抗炎、抗过敏、抗癌等多种生物学作用，在生物化学上既具有抗氧化作用，又具有促氧化作用。木樨草素的生物学效应可能在功能上相互关联。例如，抗炎活性可能与其抗癌特性有关。木犀草素的抗癌特性与诱导细胞凋亡、抑制细胞增殖、转移和血管生成有关。此外，毛地黄黄酮通过抑制细胞存活途径如磷脂酰肌醇3′-激酶（PI 3 K）/Akt、核因子κ B（NF-κB）和X连锁凋亡抑制蛋白（XIAP），以及刺激凋亡途径（包括诱导肿瘤抑制因子p53的途径），使癌细胞对治疗诱导的细胞毒性敏感。这些观察结果表明，毛地黄黄酮可能是一种抗癌剂的各种癌症。此外，最近的流行病学研究认为毛地黄黄酮具有预防癌症的特性。本文综述了近年来毛地黄黄酮的研究进展，重点介绍了毛地黄黄酮的抗肿瘤作用及其分子机制。
Luteolin, 3′,4′,5,7-tetrahydroxyflavone, is a common flavonoid that exists in many types of plants including fruits, vegetables, and medicinal herbs. Plants rich in luteolin have been used in Chinese traditional medicine for treating various diseases such as hypertension, inflammatory disorders, and cancer. Having multiple biological effects such as anti-inflammation, anti-allergy and anticancer, luteolin functions as either an antioxidant or a pro-oxidant biochemically. The biological effects of luteolin could be functionally related to each other. For instance, the anti-inflammatory activity may be linked to its anticancer property. Luteolin's anticancer property is associated with the induction of apoptosis, and inhibition of cell proliferation, metastasis and angiogenesis. Furthermore, luteolin sensitizes cancer cells to therapeutic-induced cytotoxicity through suppressing cell survival pathways such as phosphatidylinositol 3′-kinase (PI3K)/Akt, nuclear factor kappa B (NF-κB), and X-linked inhibitor of apoptosis protein (XIAP), and stimulating apoptosis pathways including those that induce the tumor suppressor p53. These observations suggest that luteolin could be an anticancer agent for various cancers. Furthermore, recent epidemiological studies have attributed a cancer prevention property to luteolin. In this review, we summarize the progress of recent research on luteolin, with a particular focus on its anticancer role and molecular mechanisms underlying this property of luteolin.