Impact of microRNAs on ischemic stroke: From pre- to post-disease
Impact of microRNAs on ischemic stroke: From pre- to post-disease
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microRNA 对缺血性中风的影响：从病前到病后。
DOI：
10.1016/j.pneurobio.2017.08.002
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发表时间：
2018-04-01
影响因子：
6.7
通讯作者：
Luo, Yumin
中科院分区：
文献类型：
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作者：
Li, Guangwen;Morris-Blanco, Kahlilia C.;Luo, Yumin
中风是成人神经功能障碍的头号原因，在世界范围内造成沉重的社会经济负担。缺血性卒中的病因学起源和由此产生的病理过程是由多方面的分子机制级联介导的，这些分子机制部分地由转录后活性调节。越来越多的证据表明，microRNA（miRNAs）作为转录后基因沉默的重要介质在脑发育的生理学和缺血性卒中的病理学中发挥作用。在这篇综述中，我们编译的miRNAs已被报道调节各种中风的危险因素和疾病前的机制，包括高血压，动脉粥样硬化，糖尿病，随后深入分析的miRNAs在缺血性中风的发病机制，如兴奋毒性，氧化应激，炎症，凋亡，血管生成和神经发生。由于通过特定的药物和非药物疗法促进或抑制miRNA的表达可能有利于卒中后恢复，我们还强调了miRNA在临床环境中的潜在治疗价值。(C)2017爱思唯尔有限公司版权所有
Stroke is the number one cause of neurological dysfunction in adults and has a heavy socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting pathological processes are mediated by a multifaceted cascade of molecular mechanisms that are in part modulated by posttranscriptional activity. Accumulating evidence has revealed a role for microRNAs (miRNAs) as essential mediators of posttranscriptional gene silencing in both the physiology of brain development and pathology of ischemic stroke. In this review, we compile miRNAs that have been reported to regulate various stroke risk factors and pre-disease mechanisms, including hypertension, atherosclerosis, and diabetes, followed by an in-depth analysis of miRNAs in ischemic stroke pathogenesis, such as excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis and neurogenesis. Since promoting or suppressing expression of miRNAs by specific pharmaceutical and non-pharmaceutical therapies may be beneficial to post-stroke recovery, we also highlight the potential therapeutic value of miRNAs in clinical settings. (C) 2017 Elsevier Ltd. All rights reserved.