Two-component signal transduction system SaeRS is involved in competence and penicillin susceptibility in Staphylococcus epidermidis
Two-component signal transduction system SaeRS is involved in competence and penicillin susceptibility in Staphylococcus epidermidis
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双组分信号转导系统SaeRS参与表皮葡萄球菌的活性和青霉素敏感性
DOI：
10.1002/jobm.201500488
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发表时间：
2016
影响因子：
3.1
通讯作者：
Qu Di
中科院分区：
文献类型：
--
作者：
Lou Qiang;Ma Yuanfang;Qu Di
表皮葡萄球菌是引起医院感染的病原菌，其生物被膜和自溶等毒力特性受双组分信号转导系统SaeRS调控。在这项研究中，S.通过DNA微阵列或真实的-时间RT-PCR分析，确定表皮病SaeRS负调节参与感受态（comF、murF）、细胞溶解（lrgA）和自溶（lytS）的基因的表达。此外，saeRS突变体显示出比野生型菌株更高的能力和对抗生素如青霉素和苯唑西林的敏感性。本研究将有助于了解表皮葡萄球菌SaeRS的特性。
Staphylococcus epidermidis, which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two‐component signal transduction system SaeRS. In this study, theS. epidermidisSaeRS was identified to negatively regulate the expression of genes involved in competence (comF, murF), cytolysis (lrgA), and autolysis (lytS) by DNA microarray or real‐time RT–PCR analysis. In addition,saeRSmutant showed increased competence and higher susceptibility to antibiotics such as penicillin and oxacillin than the wild‐type strain. The study will be helpful for understanding the characterization of the SaeRS inS. epidermidis.