Genetic integration of behavioural and endocrine components of the stress response.
Genetic integration of behavioural and endocrine components of the stress response.
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DOI：
10.7554/elife.67126
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发表时间：
2022-02-11
期刊：
影响因子：
7.7
通讯作者：
Wilson A
中科院分区：
文献类型：
--
作者：
Houslay TM;Earley RL;White SJ;Lammers W;Grimmer AJ;Travers LM;Johnson EL;Young AJ;Wilson A
脊椎动物的应激反应包括一系列行为和生理特征，这些特征必须在功能上整合起来，以确保生物体适应急性应激源。自然选择应该有利于功能整合，从而预测这些性状的遗传整合。尽管这种遗传整合对我们理解人类和动物健康以及对自然和人为压力源的进化反应具有重要意义，但缺乏对这种预测的正式定量遗传测试。在这里，我们证明了特立尼达孔雀鱼的急性应激反应成分既可遗传，又整合在遗传共变的主要轴上。这种整合可以促进或限制对选择的进化反应，这取决于选择与这个轴的对齐。这种整合还表明，对遗传相关的应激行为反应进行人工选择，可能为改善圈养动物种群的健康和福利提供一条可行的非侵入性途径。
The vertebrate stress response comprises a suite of behavioural and physiological traits that must be functionally integrated to ensure organisms cope adaptively with acute stressors. Natural selection should favour functional integration, leading to a prediction of genetic integration of these traits. Despite the implications of such genetic integration for our understanding of human and animal health, as well as evolutionary responses to natural and anthropogenic stressors, formal quantitative genetic tests of this prediction are lacking. Here, we demonstrate that acute stress response components in Trinidadian guppies are both heritable and integrated on the major axis of genetic covariation. This integration could either facilitate or constrain evolutionary responses to selection, depending upon the alignment of selection with this axis. Such integration also suggests artificial selection on the genetically correlated behavioural responses to stress could offer a viable non-invasive route to the improvement of health and welfare in captive animal populations.