Comparison of Different Drug Susceptibility Test Methods To Detect Rifampin Heteroresistance in Mycobacterium tuberculosis
Comparison of Different Drug Susceptibility Test Methods To Detect Rifampin Heteroresistance in Mycobacterium tuberculosis
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DOI：
10.1128/aac.02778-14
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发表时间：
2014-09-01
影响因子：
4.9
通讯作者：
Liu, Changting
中科院分区：
文献类型：
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作者：
Zhang, Zhijian;Wang, Yufeng;Liu, Changting
我们比较了不同的药敏试验方法在检测结核分枝杆菌对利福平(RIF)异质性耐药方面的效率。我们的数据显示，在低耐药组中，肉汤稀释法的耐药率高于甲氧西林(P=0.046)。同样，肉汤稀释法在检测低生长速率亚群的RIF异质性耐药时比MGIT法更敏感(P=0.033)。综上所述，我们的数据表明，肉汤稀释法在检测RIF异质性耐药方面比MGIT法更敏感。
We compared the efficiencies of different drug susceptibility testing methods in detecting rifampin (RIF) heteroresistance in Mycobacterium tuberculosis. Our data revealed that the broth dilution method found more resistance than MGIT did (P = 0.046) for the low-resistance group. Similarly, the broth dilution method was more sensitive in detecting RIF heteroresistance in subpopulations with low growth rates than was MGIT (P = 0.033). In conclusion, our data demonstrated that the broth dilution method was more sensitive than MGIT in detecting RIF heteroresistance.