Self-adhering implantable device of titanium: Enhanced soft-tissue adhesion by sandblast pretreatment
Self-adhering implantable device of titanium: Enhanced soft-tissue adhesion by sandblast pretreatment
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DOI：
10.1016/j.colsurfb.2021.112283
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发表时间：
2021-12-15
影响因子：
5.8
通讯作者：
Matsumoto，Takuya
中科院分区：
文献类型：
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作者：
Yabe，Atsushi;Okada，Masahiro;Matsumoto，Takuya
由金属生物材料制成的自粘式植入装置可以固定在体内，无需缝合或有机胶水，将是预防植入后装置迁移等装置相关并发症的最佳装置。我们之前报道过，经过酸处理的商业纯钛（CpTi）可以立即直接粘附在含水非角化软组织上。在此，我们研究了喷砂作为酸处理 CpTi 预处理对提高其软组织粘附性的影响。首先，研究了喷砂条件（即压力、距离和时间）对喷砂表面积和 CpTi 薄膜变形程度（即内应力形成）的影响。使用小鼠真皮组织进行离体剪切粘附试验，研究喷砂对酸处理的 CpTi 的直接软组织粘附的影响。与未喷砂的对应物 (41 ± 2 kPa) 相比，最佳喷砂预处理显着提高了酸处理 CpTi 的软组织粘附强度 (102 ± 19 kPa)。最后，CpTi粘合剂被应用于在体内固定近场通信（NFC）设备，并被证明对肌肉筋膜具有很强的即时粘合力。
Self-adhering implantable devices, which can be immobilized inside the bodies without suturing nor organic glues, made of metallic biomaterials would be optimal devices for preventing device-related complications such as device migration after implantation. We reported previously that acid-treated commercially-pure titanium (CpTi) adhered directly and immediately on hydrous non-keratinized soft tissues. Herein, we investigated the influence of sandblasting as pretreatment for acid-treated CpTi to increase its soft tissue adhesiveness. First, the effects of sandblasting conditions (i.e., pressure, distance and time) were investigated in terms of the sandblasted surface area and the degree of deformation (i.e., internal stress formation) of CpTi films. The effect of the sandblasting on the immediate soft tissue adhesion of acid-treated CpTi was investigated using anex vivoshear adhesion test with mouse dermal tissues. The optimal sandblasting pretreatment remarkably improved the soft tissue adhesion strength of acid-treated CpTi (102 ± 19 kPa) compared with the non-sandblasted counterparts (41 ± 2 kPa). Finally, the CpTi adhesive was applied for immobilizing a near field communication (NFC) devicein vivo, and was shown to have strong immediate adhesion to muscle fascia.