Psychophysical measurement of rod and cone thresholds in stargardt disease with full-field stimuli.
Psychophysical measurement of rod and cone thresholds in stargardt disease with full-field stimuli.
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DOI：
10.1097/iae.0000000000000144
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Allikmets R
中科院分区：
文献类型：
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作者：
Collison FT;Fishman GA;McAnany JJ;Zernant J;Allikmets R
目的：用全视野刺激试验（FST）研究Stargardt病的心理物理阈值。视力（VA），光谱域光学相干断层扫描（SD-OCT），全视野视网膜电图（ERG），和FST测量在一只眼睛的24例Stargardt病。暗适应视杆细胞FST阈值是用短波长刺激测量的，而视锥细胞FST阈值是用长波长刺激从暗适应的视锥细胞平台期获得的。计算FST阈值与黄斑厚度、VA和ERG振幅的相关系数。Stargardt患者FST视锥阈值与VA、黄斑厚度和ERG视锥反应幅度显著相关（均P<0.01）。患者的FST视杆阈值与ERG视杆反应幅度相关（P<0.01），但与黄斑厚度无关（P=0.05）。所有的Stargardt病患者的皮瓣局限于黄斑和大多数患者的皮瓣延伸到黄斑外的FST阈值正常。所有黄斑外萎缩性改变的患者FST视锥阈值升高，大多数FST视杆阈值升高。Stargardt病患者的FST视杆和视锥阈值升高与结构和功能以及检眼镜视网膜外观的测量结果相关。FST似乎是评估Stargardt病视杆细胞和视锥细胞功能的有用工具。
To investigate psychophysical thresholds in Stargardt disease with the full-field stimulus test (FST). Visual acuity (VA), spectral-domain optical coherence tomography (SD-OCT), full-field electroretinogram (ERG), and FST measurements were made in one eye of 24 patients with Stargardt disease. Dark-adapted rod FST thresholds were measured with short-wavelength stimuli, and cone FST thresholds were obtained from the cone plateau phase of dark adaptation using long-wavelength stimuli. Correlation coefficients were calculated for FST thresholds versus macular thickness, VA and ERG amplitudes. Stargardt patient FST cone thresholds correlated significantly with VA, macular thickness, and ERG cone-response amplitudes (all P<0.01). The patients’ FST rod thresholds correlated with ERG rod-response amplitudes (P<0.01), but not macular thickness (P=0.05). All Stargardt disease patients with flecks confined to the macula and most of the patients with flecks extending outside of the macula had normal FST thresholds. All patients with extramacular atrophic changes had elevated FST cone thresholds and most had elevated FST rod thresholds. FST rod and cone threshold elevation in Stargardt disease patients correlated well with measures of structure and function, as well as ophthalmoscopic retinal appearance. FST appears to be a useful tool for assessing rod and cone function in Stargardt disease.