Reduction of stress-induced analgesia following ethanol exposure in mice.
Reduction of stress-induced analgesia following ethanol exposure in mice.
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DOI：
10.1016/s0024-3205(98)00328-2
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发表时间：
1998-07
期刊：
影响因子：
6.1
通讯作者：
R. Bell;R. Soignier;R. Olson;A. Vaccarino
中科院分区：
文献类型：
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作者：
R. Bell;R. Soignier;R. Olson;A. Vaccarino
在本研究中，我们研究了乙醇处理对阿片类和非阿片类形式的游泳应激镇痛（SSIA）的后续表达的影响。在实验1中，每天一次给小鼠注射乙醇（2.5 g/kg，IP）或等体积的盐水，持续两天。动物在第3天未接受处理。在第4天，在热板测试（52 ° C）中测试动物的阿片样物质（在维持在32 °C的水中游泳3分钟）或非阿片样物质（在维持在20 °C的水中游泳3分钟）SSIA。用乙醇注射预处理的小鼠显示非阿片类SSIA减少，但阿片类SSIA没有减少。在实验2中，给小鼠饮用乙醇溶液（10%）或自来水15天。在第16天，所有动物均饮用自来水。在第17天，测试动物的阿片类或非阿片类SSIA。在饮用乙醇溶液的小鼠中，SSIA的两种形式都没有改变。这些结果表明，乙醇预处理可以改变小鼠的非阿片类内源性镇痛反应。此外，给药途径影响乙醇预处理对SSIA的影响。
In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, IP) or an equal volume of saline once a day for two days. Animals received no treatment on day 3. On day 4, the animals were tested for opioid (3-min swim in water maintained at 32 °C) or nonopioid (3-min swim in water maintained at 20 °C) SSIA in the hotplate test (52 °C). Mice pretreated with ethanol injections showed a decrease in nonopioid SSIA, but not in opioid SSIA. In Experiment 2, mice were given an ethanol solution (10%) or tap water to drink for 15 days. On day 16, all animals were given tap water to drink. On day 17, the animals were tested for opioid or nonopioid SSIA. Neither form of SSIA was modified in mice that drank the ethanol solution. These results show that ethanol pretreatment can modify nonopioid endogenous analgesic responses in mice. Further, the route of administration influences the effects of ethanol pretreatment on SSIA.