Merkel cell carcinoma. A successful treatment with tumor necrosis factor.
Merkel cell carcinoma. A successful treatment with tumor necrosis factor.
复制标题
默克尔细胞癌。
DOI：
10.1001/archderm.1989.01670200069011
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发表时间：
1989
影响因子：
--
通讯作者：
M. Takahashi
中科院分区：
文献类型：
--
作者：
Y. Ito;K. Kawamura;T. Miura;K. Ueda;H. Onodera;H. Takahashi;T. Horikoshi;S. Sugiyama;M. Takahashi
通过直接瘤内注射重组人肿瘤坏死因子，成功治愈了一名 78 岁女性下颌默克尔细胞癌。患者每隔一天接受 2.5 x 10(5) U/d 重组人肿瘤坏死因子。在 12 天内总共进行了六次注射（总剂量为 1.5 x 10(6) U，0.52 mg 蛋白质）。治疗结束后不久，病变软化并缩小。 1个月后，仅可见红斑。局部注射重组人肿瘤坏死因子5个月后，病灶在临床和组织学上完全消失。治疗后至少 12 个月内未观察到复发或转移。重组人肿瘤坏死因子被认为可有效治疗默克尔细胞癌。
A Merkel cell carcinoma of the mandibular area in a 78-year-old woman was treated successfully by direct intratumoral administration of recombinant human tumor necrosis factor. The patient received 2.5 x 10(5) U/d of recombinant human tumor necrosis factor every other day. A total of six injections (total dose, 1.5 x 10(6) U, 0.52 mg of protein) were administered over a period of 12 days. Soon after the therapy ended, the lesion softened and decreased in size. After 1 month, only erythema was visible. The lesion had completely disappeared clinically and histologically 5 months after the local injection of recombinant human tumor necrosis factor. Neither recurrence nor metastasis has been observed for at least 12 months following the treatment. Recombinant human tumor necrosis factor is suggested to be effective for the treatment of Merkel cell carcinoma.