Lithium blocks a phosphoinositide-mediated cholinergic response in hippocampal slices.
Lithium blocks a phosphoinositide-mediated cholinergic response in hippocampal slices.
复制标题
锂可阻断海马切片中磷酸肌醇介导的胆碱能反应。
DOI：
10.1126/science.2831626
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Baraban,JM
中科院分区：
文献类型：
--
作者：
Worley,PF;Heller,WA;Snyder,SH;Baraban,JM
锂对肌醇磷酸代谢的影响可能是锂治疗情感性精神障碍的原因之一。毒碱刺激磷脂酰肌醇系统可阻断腺苷在海马片的突触抑制作用。在治疗浓度下，锂减弱了这种毒碱反应，而不影响磷脂酰肌醇代谢的Rb则没有影响。抑制磷脂酰肌醇介导的神经传递可能解释了锂在治疗躁狂症和抑郁症方面的正常化效果。
The effects of lithium on inositol phosphate metabolism may account for the therapeutic actions of lithium in affective disorder. Muscarinic stimulation of the phosphoinositide system blocks synaptic inhibitory actions of adenosine in the hippocampal slice. At therapeutic concentrations, lithium diminished this muscarinic response, whereas rubidium, which does not affect phosphoinositide metabolism, had no effect. A dampening of phosphoinositide-mediated neurotransmission may explain the normalizing effects of lithium in treating both mania and depression.