Endoscopic implantation of Plexiglas (PMMA) microspheres for the treatment of GERD
Endoscopic implantation of Plexiglas (PMMA) microspheres for the treatment of GERD
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DOI：
10.1067/mge.2001.113912
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发表时间：
2001-04-01
影响因子：
7.7
通讯作者：
Apostolidis, N
中科院分区：
文献类型：
--
作者：
Feretis, C;Benakis, P;Apostolidis, N
背景：含有聚甲基丙烯酸甲酯(PMMA)微珠的凝胶植入物成功地用于增加皮肤缺损和皱纹患者的绒毛厚度，本研究的目的是确定将PMMA微球注入食道下皱褶是否能减轻GERD患者的症状和酸反流。方法：对10例对质子泵抑制剂无效或依赖的GERD患者进行了内窥镜下黏膜下PMMA植入。结果：PMMA植入后症状严重程度评分和食道pH<4的平均总时间显著减少(p<；0.05)。10例患者中有7例术后未用药，无严重并发症发生。结论：内窥镜下食道皱褶黏膜下层植入PMMA可能是治疗GERD的一种新方法，其远期疗效有待进一步研究。
Background: A gelatinous implant containing polymethylmethacrylate (PMMA) beads is successfully used to augment the diminished thickness of the chorium in patients with skin defects and wrinkles, The aim of the present study was to determine whether submucosal injection of PMMA microspheres into the lower esophageal folds decreases the severity of symptoms and acid reflux in patients with GERD.Methods: Endoscopic submucosal implantation of PMMA was carried out in 10 patients with GERD who were either refractory to or dependent on proton pump inhibitors. Symptom severity score, 24-hour pH monitoring, upper GI endoscopy, and EUS were performed to evaluate the efficacy of implantation.Results: A significant decrease in the symptom severity score and mean total time with esophageal pH less than 4 was noted after the implantation of PMMA (p < 0.05). Seven of 10 patients were taking no medication after PMMA implantation, There were no serious procedure-related complications.Conclusions: Endoscopic implantation of PMMA into the submucosa of the lower esophageal folds may be a new method for treating GERD, Further studies are required to determine the longterm efficacy of the procedure.