CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala.
CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala.
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DOI：
10.1038/nn.2405
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发表时间：
2009-11
影响因子：
25
通讯作者：
Silva, Alcino J.
中科院分区：
文献类型：
--
作者：
Zhou, Yu;Won, Jaejoon;Karlsson, Mikael Guzman;Zhou, Miou;Rogerson, Thomas;Balaji, Jayaprakash;Neve, Rachael;Poirazi, Panayiota;Silva, Alcino J.
决定信息如何分配到大脑中特定区域和细胞的机制对于记忆容量、存储和检索至关重要，但人们对此知之甚少。在这里，我们操纵CREB在侧杏仁核（LA）神经元的一个子集与修改后的单纯疱疹病毒（HSV），和可逆失活转染的神经元与果蝇allatostatin G-蛋白偶联受体（AlstR）/配体系统。我们发现，失活的HSV-CREB亚群的神经元与allatostatin（AL）在训练中破坏记忆的音调条件反射，而失活的HSV-LacZ控制神经元的相似比例没有。荧光标记的HSV-CREB神经元的全细胞记录显示，具有较高CREB水平的神经元比邻近神经元更易兴奋，并且在条件反射后显示出更大的突触功效变化。我们的研究结果表明，CREB调节恐惧记忆向外侧杏仁核特定细胞的分配，并表明神经元兴奋性在这一过程中发挥关键作用。
The mechanisms that determine how information is allocated to specific regions and cells in the brain are fundamentally important for memory capacity, storage and retrieval, but are poorly understood. Here, we manipulated CREB in a subset of lateral amygdala (LA) neurons with a modified Herpes Simplex Virus (HSV), and reversibly inactivated transfected neurons with the Drosophila allatostatin G-protein-coupled receptor (AlstR)/ligand system. We found that inactivation of the HSV-CREB subpopulation of neurons with allatostatin (AL) during training disrupted memory for tone conditioning, while inactivation of a similar proportion of HSV-LacZ control neurons did not. Whole-cell recordings of fluorescently tagged HSV-CREB neurons revealed that neurons with higher CREB levels are more excitable than neighboring neurons, and show larger synaptic efficacy changes following conditioning. Our findings demonstrate that CREB modulates the allocation of fear memory to specific cells in lateral amygdala, and suggest that neuronal excitability plays a key role in this process.
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兴奋性和抑制性可塑性对突触驱动的神经元输出输出功能的差异影响。
影响因子：
16.2
作者：
Carvalho, Tiago P.;Buonomano, Dean V.
通讯作者：
Buonomano, Dean V.
影响因子：
5.3
作者：
Han, MH;Bolanos, CA;Nestler, EJ
通讯作者：
Nestler, EJ
影响因子：
25
作者：
Kida, S;Josselyn, SA;Silva, AJ
通讯作者：
Silva, AJ
影响因子：
5.3
作者：
Clark, MS;Sexton, TJ;Neumaier, JF
通讯作者：
Neumaier, JF
DOI：
10.1073/pnas.0807708106
发表时间：
2009-02-03
影响因子：
11.1
作者：
Oh, M. Matthew;McKay, Bridget M.;Disterhoft, John F.
通讯作者：
Disterhoft, John F.