DIFFERENTIAL-EFFECTS OF EXCITOTOXIC LESIONS OF THE BASOLATERAL AMYGDALA, VENTRAL SUBICULUM AND MEDIAL PREFRONTAL CORTEX ON RESPONDING WITH CONDITIONED REINFORCEMENT AND LOCOMOTOR-ACTIVITY POTENTIATED BY INTRAACCUMBENS INFUSIONS OF D-AMPHETAMINE
DIFFERENTIAL-EFFECTS OF EXCITOTOXIC LESIONS OF THE BASOLATERAL AMYGDALA, VENTRAL SUBICULUM AND MEDIAL PREFRONTAL CORTEX ON RESPONDING WITH CONDITIONED REINFORCEMENT AND LOCOMOTOR-ACTIVITY POTENTIATED BY INTRAACCUMBENS INFUSIONS OF D-AMPHETAMINE
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DOI：
10.1016/0166-4328(93)90113-5
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发表时间：
1993-06-30
影响因子：
2.7
通讯作者：
EVERITT, BJ
中科院分区：
文献类型：
--
作者：
BURNS, LH;ROBBINS, TW;EVERITT, BJ
这里报道的实验已经调查了奖励相关的过程中，基底外侧杏仁核，腹侧下托和前边缘皮层，代表了主要的边缘来源的传入腹侧纹状体病变的影响。结果表明，虽然病变的前边缘皮层是没有影响的方法CS预测的蔗糖强化和收购一个新的反应与条件强化，病变的其他两个结构显着损害这两个反应。然而，基底外侧杏仁核和腹侧下托病变的影响之间有重要的差异。因此，腹侧下托的病变完全取消了运动反应的intra-adrenbens注入D-安非他明，除了阻断的潜在作用，相同的治疗与条件强化的反应。相比之下，基底外侧杏仁核的病变，减少了对行为的控制，由一个条件反射器，但不是增强的控制，由intra-adrenbens D-安非他明，除非在最高剂量。此外，在腹侧下托病变阻断的剂量范围内，杏仁核病变对D-苯丙胺诱导的多巴胺增加的运动反应不受影响。结果提示杏仁核-腹侧纹状体的相互作用对条件强化过程的影响具有相当的选择性，而腹侧下托-腹侧纹状体的相互作用在介导D-苯丙胺的精神兴奋效应中具有更根本的影响。
The experiments reported here have investigated the impact on reward-related processes of lesioning the basolateral amygdala, ventral subiculum and prelimbic cortex which represent the major limbic sources of afferents to the ventral striatum. The results showed that, while lesions of the prelimbic cortex were without effect on the approach to a CS predictive of sucrose reinforcement and the acquisition of a new response with conditioned reinforcement, lesions of the other two structures significantly impaired both responses. However, there were important differences between the effects of basolateral amygdala and ventral subiculum lesions. Thus, lesions of the ventral subiculum completely abolished the locomotor response to intra-accumbens infusions Of D-amphetamine, in addition to blocking the potentiative effect of the same treatment on responding with conditioned reinforcement. Lesions of the basolateral amygdala, by contrast, reduced the control over behaviour by a conditioned reinforcer, but not the potentiation of that control by intra-accumbens D-amphetamine except at the highest dose. Moreover, the locomotor response to D-amphetamine-induced increases in dopamine in the nucleus accumbens was unaffected by amygdala lesions over the dose range blocked by ventral subiculum lesions. The results suggest a rather selective effect of amygdala-ventral striatal interactions on processes subserving conditioned reinforcement and a more fundamental influence of ventral subiculum-ventral striatal interactions in mediating the psychomotor stimulant effects Of D-amphetamine.