The Effect of Age on Mortality in Patients With COVID-19: A Meta-Analysis With 611,583 Subjects
The Effect of Age on Mortality in Patients With COVID-19: A Meta-Analysis With 611,583 Subjects
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DOI：
10.1016/j.jamda.2020.05.045
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发表时间：
2020-07-01
影响因子：
7.6
通讯作者：
Cordero, Alberto
中科院分区：
文献类型：
--
作者：
Bonanad, Clara;Garcia-Blas, Sergio;Cordero, Alberto
目的：新冠肺炎感染的初步数据指出了老年人的特殊易感性。设计：我们利用2020年5月7日来自意大利、西班牙、英国和纽约州的中国的全国性报告进行了荟萃分析。通过随机效应模型进行分析，并进行敏感性分析以确定潜在的异质性来源。背景和对象：文献和国家报告中报告的COVID-19阳性患者。测量：按年龄分类的全原因死亡率。结果：总共分析了611,1583名受试者，其中141,745名(23.2%)年龄<80岁。5个登记处的八旬老人比例不同，中国最低(3.2%)，英国和纽约州最高。总死亡率为12.10%，各国差异很大，最低的是中国(3.1%)，最高的是英国(20.8%)和纽约州(20.99%)。死亡率为50岁，尤其是60岁。在实施预防措施时，应优先考虑老年患者。(C)2020年AMDA--急性后和长期护理医学学会。
Objectives: Initial data on COVID-19 infection has pointed out a special vulnerability of older adults.Design: We performed a meta-analysis with available national reports on May 7, 2020 from China, Italy, Spain, United Kingdom, and New York State. Analyses were performed by a random effects model, and sensitivity analyses were performed for the identification of potential sources of heterogeneity.Setting and participants: COVID-19epositive patients reported in literature and national reports.Measures: All-cause mortality by age.Results: A total of 611,1583 subjects were analyzed and 141,745 (23.2%) were aged >= 80 years. The percentage of octogenarians was different in the 5 registries, the lowest being in China (3.2%) and the highest in the United Kingdom and New York State. The overall mortality rate was 12.10% and it varied widely between countries, the lowest being in China (3.1%) and the highest in the United Kingdom (20.8%) and New York State (20.99%). Mortality was 50 years and, especially, >60 years. Older adult patients should be prioritized in the implementation of preventive measures. (C) 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine.