Vitamin D homeostasis in the perinatal period: 1,25-dihydroxyvitamin D in maternal, cord, and neonatal blood.
Vitamin D homeostasis in the perinatal period: 1,25-dihydroxyvitamin D in maternal, cord, and neonatal blood.
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围产期维生素 D 稳态：母体、脐带和新生儿血液中的 1,25-二羟基维生素 D。
DOI：
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发表时间：
1980
影响因子：
158.5
通讯作者：
H. DeLuca
中科院分区：
文献类型：
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作者：
J. Steichen;R. Tsang;T. Gratton;A. Hamstra;H. DeLuca
为了研究维生素D在足月妊娠中的稳态，我们测量了19名足月孕妇的血清样本及其婴儿胎盘静脉样本中的1,25-二羟基维生素D （1,25(OH)2D）。样本取自14名24小时大的新生儿。分娩时，母体1.25 (OH)2D浓度高于正常成人水平；婴儿胎盘静脉浓度明显低于成人正常值或母体值，与母体值无关。当婴儿达到24小时的年龄时，他们的血清浓度已达到正常的成人值，并伴有血清离子钙浓度的下降。我们推测，子宫内较低的1,25(OH)2D浓度表明胎儿不需要肠道钙吸收。产后125 (OH)2D的增加可能是由于它的产生是满足子宫外小肠吸收钙和磷需求的先决条件。
To investigate vitamin D homeostasis in term pregnancy, we measured 1,25-dihydroxyvitamin D (1,25(OH)2D) in serum samples from 19 term pregnant women and in samples from the placental veins of their infants. Samples were obtained from 14 neonates at 24 hours of age. At delivery, maternal concentrations of 1,25(OH)2D were elevated above normal adult values; placental-vein concentrations in the infants were significantly lower than adult normal or maternal values and bore no relation to maternal values. By the time the infants reached 24 hours of age, their serum concentrations had reached normal adult values, concomitant with a decrease in serum concentration of ionized calcium. We speculate that low 1,25(OH)2D concentrations in utero suggest that there is no need for intestinal calcium absorption in the fetus. Postnatal increase of 1,25(OH)2D may result from its production as a prerequisite to extrauterine requirements for intestinal absorption of calcium and phosphorus.