Peritumoral interstitial fluid flow velocity predicts survival in cervical carcinoma
Peritumoral interstitial fluid flow velocity predicts survival in cervical carcinoma
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DOI：
10.1016/j.radonc.2014.09.011
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发表时间：
2014-10-01
影响因子：
5.7
通讯作者：
Rofstad, Einar K.
中科院分区：
文献类型：
--
作者：
Hompland, Tord;Lund, Kjersti V.;Rofstad, Einar K.
背景和目的：肿瘤间质液压力（IFP）升高与局部晚期宫颈癌预后不良相关。我们最近开发了一种肿瘤IFP的非侵入性测定法，在该测定法中，通过基于Gd-DTPA的DCE-MRI测量肿瘤表面向外的间质液流速（v（0）），并将其用作IFP的参数。在此，我们研究了v（0）在接受以顺铂为基础的同步放化疗的宫颈癌患者中的独立预后意义。（IB至IIIB期），中位随访时间为5.5年。5年无病生存率（DFS）和总生存率（OS）分别为67%和76%。在总患者队列和40例IIB期患者的子队列中，均发现关于中位数的二分v（0）与DFS和OS之间存在显著相关性。多变量分析涉及阶段，肿瘤体积，淋巴结状态，和v（0）显示，只有v（0）提供独立的预后信息DFS和OS.Conclusion：这项调查表明，一个强大的，独立的预后影响宫颈癌的预处理瘤周液流速。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Background and purpose: High tumor interstitial fluid pressure (IFP) is associated with poor outcome in locally advanced carcinoma of the uterine cervix. We have recently developed a noninvasive assay of the IFP of tumors, and in this assay, the outward interstitial fluid flow velocity at the tumor surface (v(0)) is measured by Gd-DTPA-based DCE-MRI and used as a parameter for IFP. Here, we investigated the independent prognostic significance of v(0) in cervical cancer patients given cisplatin-based concurrent chemoradiotherapy with curative intent.Patients: The study involved 62 evaluable patients from a cohort of 74 consecutive patients (Stage IB through IIIB) with a median follow-up of 5.5 years.Results: The actuarial disease-free survival (DFS) and overall survival (OS) at 5 years were 67% and 76%, respectively. Significant associations were found between v(0) dichotomized about the median value and DFS and OS, both in the total patient cohort and a subcohort of 40 Stage IIB patients. Multivariate analysis involving stage, tumor volume, lymph node status, and v(0) revealed that only v(0) provided independent prognostic information about DFS and OS.Conclusion: This investigation demonstrates a strong, independent prognostic impact of the pretreatment peritumoral fluid flow velocity in cervical cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.