HEAT-SHOCK PROTEINS AND DRUG-RESISTANCE
HEAT-SHOCK PROTEINS AND DRUG-RESISTANCE
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DOI：
10.1007/bf00666207
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发表时间：
1994-01-01
影响因子：
3.8
通讯作者：
OSBORNE, CK
中科院分区：
文献类型：
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作者：
FUQUA, SAW;OESTERREICH, S;OSBORNE, CK
当细胞暴露于不同的环境应激条件时，热休克蛋白（hsp’s）在细胞中被诱导。我们发现乳腺癌细胞有时表达高水平的几种热休克蛋白，这可能会增加这些肿瘤的侵袭性，使它们对治疗更有抵抗力。我们已经证明，在淋巴结阴性的乳腺肿瘤中，通过Western blot检测到hsp70是一个不祥的预后信号，并且hsp27增加了乳腺癌细胞系对阿霉素的特异性耐药性。这些发现具有直接的临床应用价值。并提示调节热休克蛋白的表达可能是逆转热休克蛋白相关的有害细胞效应的治疗靶点。
Heat shock proteins (hsp's) are induced in cells when exposed to different environmental stressful conditions. We have found that breast cancer cells sometimes express high levels of several hsp's, which may both augment the aggressiveness of these tumors and make them more resistant to treatment. We have shown that hsp70 is an ominous prognostic sign as detected by Western blot assays in node-negative breast tumors, and that hsp27 increases specific resistance to doxorubicin in breast cancer cell lines. These findings have direct clinical application. and suggest that modulating hsp expression may be a therapeutic target for reversal of hsp-associated detrimental cellular effects.