RECENT STUDIES OF THE GLIAL FIBRILLARY ACIDIC PROTEIN
RECENT STUDIES OF THE GLIAL FIBRILLARY ACIDIC PROTEIN
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DOI：
10.1111/j.1749-6632.1985.tb50433.x
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发表时间：
1985-10-31
影响因子：
5.2
通讯作者：
SKOFF, RP
中科院分区：
文献类型：
--
作者：
ENG, LF;SMITH, ME;SKOFF, RP
在中枢神经系统（CNS）中，星形胶质细胞被认为根据CNS的发育、正常或疾病状态执行各种代谢和结构功能。慢性神经系统疾病，例如由脊髓和脑创伤、多发性硬化、脑血管疾病、衰老和阿尔茨海默氏痴呆引起的那些，都与不同程度的星形胶质细胞神经胶质增生有关。在任何类型的中枢神经系统创伤的反应，星形胶质细胞增殖和增加的大小，其胞质过程变得更大，更曲折，并有一个中间胶质纤维的数量和胶质细胞酸性蛋白（GFAP）的含量大幅增加。反应性GFAP积累的机制是一个积极探索的领域。这可能是由于降解减少所致。在培养中生长的连续人胶质瘤细胞系中GFAP的快速蛋白水解降解和
In the central nervous system (CNS) astrocytes are thought to perform a variety of metabolic and structural functions depending on the developmental, normal, or disease state of the CNS. Chronic neurological diseases, such as those resulting from trauma to the spinal cord and brain, multiple sclerosis, cerebral vascular disease, aging, and Alzheimer’s dementia all are associated with varying degrees of astrocytic gliosis. In response to CNS trauma of any kind, astrocytes proliferate and increase in size; their cytoplasmic processes become larger and more torturous; and there is a substantial increase in the number of intermediate glial filaments and in glial fibrillary acidic protein (GFAP) content. The mechanism of reactive GFAP accumulation is an area of active inquiry. It could result from decreased degradation. Rapid proteolytic degradation of the GFAP in a continuous human glioma cell line grown in culture and