HUMAN NEURONAL PENTRAXIN-II (NPTX2) - CONSERVATION, GENOMIC STRUCTURE, AND CHROMOSOMAL LOCALIZATION
HUMAN NEURONAL PENTRAXIN-II (NPTX2) - CONSERVATION, GENOMIC STRUCTURE, AND CHROMOSOMAL LOCALIZATION
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DOI：
10.1006/geno.1995.1134
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发表时间：
1995-07-20
期刊：
影响因子：
4.4
通讯作者：
PERIN, MS
中科院分区：
文献类型：
--
作者：
HSU, YC;PERIN, MS
我们以前已经确定了一种新的大鼠神经元成员的pentraxin家族（神经元pentraxin），可能介导的突触材料和突触前蛇毒毒素，taipoxin的摄取。在这里，我们报告人类的cDNA和基因组序列的第二个神经元pentraxin。这种五聚蛋白，我们建议命名为神经元五聚蛋白LI（NPII;基因符号NPTX 2），显示54%的氨基酸同一性，大鼠神经元五聚蛋白（NPI）与69%的同一性超过羧基末端一半的NPI和88%的同一性，新确定的精子顶体五聚蛋白p50/apexin。北方印迹分析揭示，NPII信息存在于脑、睾丸、胰腺、肝脏、心脏和骨骼肌中，因此，与NPI不同，NPII并非仅定位于神经元。与NPI一样，NPII具有潜在的N-连接糖基化位点。人NPII基因长11 kb，含有4个内含子，定位于染色体7q21.3-q22.1。这些数据表明存在一个五聚蛋白家族，其在脑和其他组织中表达，并且可能在细胞外物质的摄取中发挥重要作用。(C)出版社：Academic Press
We have previously identified a novel rat neuronal member of the pentraxin family (neuronal pentraxin) that may mediate the uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Here we report human cDNA and genomic sequences of a second neuronal pentraxin. This pentraxin, which we propose to name neuronal pentraxin LI (NPII; gene symbol NPTX2), shows 54% amino acid identity to rat neuronal pentraxin (NPI) with 69% identity over the carboxyl-terminal half of NPI and is 88% identical to a newly identified sperm acrosomal pentraxin p50/apexin. Northern blot analysis reveals that NPII message is present in brain, testis, pancreas, liver, heart, and skeletal muscle, so, unlike NPI, NPII is not exclusively localized to neurons. Like NPI, NPII has potential N-linked glycosylation sites. The human NPII gene is 11 kb in length, contains four introns, and is localized to chromosome 7q21.3-q22.1. These data demonstrate the existence of a family of pentraxin proteins that are expressed in the brain and other tissues and that may play important roles in the uptake of extracellular material. (C) 1995 Academic Press, Inc.