Stability of c-K-ras amplification during progression in a patient with adenocarcinoma of the ovary.
Stability of c-K-ras amplification during progression in a patient with adenocarcinoma of the ovary.
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发表时间：
1985-09
期刊：
影响因子：
11.2
通讯作者：
J. Filmus;R. Buick'
中科院分区：
文献类型：
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作者：
J. Filmus;R. Buick'
我们发现一例卵巢浆液性囊腺癌，肿瘤细胞显示K-ras癌基因扩增（10 ~ 20倍）。从恶性腹水中纯化的正常细胞未显示这种扩增。在患者接受化疗并经历临床进展的9个月期间，通过穿刺术获得5个连续样本。在此期间，肿瘤细胞中的c-K-ras扩增水平没有变化。在对另外6例卵巢腺癌患者和5个相同组织学的细胞系的肿瘤研究中，我们没有检测到其他显著的c-K-ras扩增的例子。
We have identified a case of serous cystadenocarcinoma of the ovary in which the tumor cells display an amplification (from 10- to 20-fold) of the cellular oncogene K-ras. Normal cells purified from the malignant ascites did not show such amplification. Five consecutive samples were obtained by paracentesis over a 9-month period during which the patient received chemotherapy and underwent clinical progression. The level of c-K-ras amplification in the tumor cells did not change during this period. In studies of the tumors of 6 additional patients with adenocarcinoma of the ovary and 5 cell lines of the same histology, we have detected no other example of significant c-K-ras amplification.