Estimation of cumulative cadmium intake causing Itai-itai disease
Estimation of cumulative cadmium intake causing Itai-itai disease
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DOI：
10.1016/j.toxlet.2005.05.011
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发表时间：
2005-11-15
影响因子：
3.5
通讯作者：
Nogawa, K
中科院分区：
文献类型：
--
作者：
Inaba, T;Kobayashi, E;Nogawa, K
这项研究是为了估计发生伊泰-伊泰病所需的镉(Cd)暴露量。调查对象包括1977年和1978年收治的82例伊泰病患者和1例需要观察的人。伊泰-伊泰病患者开始感觉到腿/背痛的时期被定义为“轻度疾病发作”，而他们经历最严重的表现，如行走障碍和骨折被定义为“严重疾病发作”的时期。用相对累积人口数与轻度、重度和死亡时间的镉摄入量(LCD)呈S型曲线分布，并建立概率回归线。半数ITAI-ITAI患者轻、重度起病时的LCD分别为3.1和3.8g。此外，在5%的ITAI-ITAI患者中，轻度发病时LCD为2.6克，重度发病时LCD为3.3克。目前的结果表明，伊泰-伊泰病是慢性镉中毒的最严重阶段，其镉消费量约为日本目前的三倍。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
This study was undertaken to estimate the amount of cadmium (Cd) exposure needed for the development of Itai-itai disease. The investigated subjects comprised 82 Itai-itai disease patients and I I persons requiring observation who were admitted in 1977 and 1978 for medical testing. With the period when the Itai-itai disease patients started to perceive leg/back pain defined as the 'mild disease onset', and the period when they experienced the most severe manifestations such as ambulatory disturbance and bone fractures defined as 'severe disease onset'. Relative cumulative person number distribution according to life time cadmium intake (LCD) at mild disease onset, severe disease onset, and time of death was depicted as an sigmoid curve and the establishment of probit regression lines was demonstrated between them. LCD at the time when mild disease onset and severe disease onset were recognized in half of the Itai-itai disease patients was 3.1 and 3.8 g, respectively. Furthermore, LCD at the time when mild disease onset and severe disease onset were recognized in 5% of the Itai-itai disease patients was calculated to be 2.6 and 3.3 g, respectively. The present results clarify that Itai-itai disease, the most severe stage of chronic Cd poisoning, occurs at levels of Cd consumption amounting to approximately three-fold of those currently seen in Japan. (c) 2005 Elsevier Ireland Ltd. All rights reserved.