Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease.
Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease.
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DOI：
10.3389/fimmu.2018.00963
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发表时间：
2018
影响因子：
7.3
通讯作者：
Chakraverty R
中科院分区：
文献类型：
--
作者：
Santos E Sousa P;Bennett CL;Chakraverty R
皮肤是移植物抗宿主病(GVHD)最常见的靶器官，严重程度和对治疗的反应是患者生存的重要预测因素。尽管GVHD发病机制中的许多启动事件已经被定义，但对于为什么发生治疗耐药或为什么经常出现永久性的组织内稳态恢复失败，人们知之甚少。新出现的数据表明，皮肤中独特的免疫微环境负责定义不同于其他靶器官的特定部位和上下文的损伤机制。在这篇综述中，我们阐述了我们对皮肤GVHD生物学理解的最新进展，并概述了最终将使精确治疗设计成为可能的新研究主题。
The skin is the most common target organ affected by graft-versus-host disease (GVHD), with severity and response to therapy representing important predictors of patient survival. Although many of the initiating events in GVHD pathogenesis have been defined, less is known about why treatment resistance occurs or why there is often a permanent failure to restore tissue homeostasis. Emerging data suggest that the unique immune microenvironment in the skin is responsible for defining location- and context-specific mechanisms of injury that are distinct from those involved in other target organs. In this review, we address recent advances in our understanding of GVHD biology in the skin and outline the new research themes that will ultimately enable design of precision therapies.
影响因子：
3.7
作者：
Novota P;Zinöcker S;Norden J;Wang XN;Sviland L;Opitz L;Salinas-Riester G;Rolstad B;Dickinson AM;Walter L;Dressel R
通讯作者：
Dressel R