Is there a gender-related susceptibility for cisplatin ototoxicity?
Is there a gender-related susceptibility for cisplatin ototoxicity?
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DOI：
10.1007/s00405-014-3283-0
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发表时间：
2015-10-01
影响因子：
2.6
通讯作者：
Ellidokuz, Hulya
中科院分区：
文献类型：
--
作者：
Kirkim, Gunay;Olgun, Yuksel;Ellidokuz, Hulya
耳毒性是顺铂的一种众所周知的副作用。介绍了顺铂耳毒性的遗传和非遗传危险因素。虽然有一些研究指出顺铂肾毒性和神经毒性的性别差异，但还没有研究顺铂耳毒性的性别差异。本研究旨在揭示大鼠对顺铂耳毒性的易感性是否存在性别差异。雄性Wistar大鼠14只，雌性Wistar大鼠14只，随机分为4组：雌性对照组、雄性对照组、雌性顺铂组和雄性顺铂组。测量失真产物耳声发射和听性脑干反应。顺铂组给予顺铂16 mg/kg。第4天复查听力学检查。处死后取耳蜗组织和脑干组织进行光镜和电子显微镜观察。雌性大鼠顺铂组的听力比雄性大鼠顺铂组的听力恶化更严重。组织病理学检查显示雌性大鼠螺旋神经节和脑干组织损伤较重。应用顺铂后，雌性大鼠的听力比雄性大鼠的听力恶化更严重。这种听力上的差异可以归因于螺旋神经节细胞和脑干神经元等神经元组织中出现的更严重的损伤。
Ototoxicity is a well-known side effect of cisplatin. Some genetic and non-genetic risk factors were described for cisplatin ototoxicity. Although there are some studies which point out a sex-related difference for cisplatin nephrotoxicity and neurotoxicity, sex-related differences for cisplatin ototoxicity have not been studied. The aim of this study is to reveal whether there is any gender-related difference for susceptibility to cisplatin ototoxicity in rats. Fourteen male, 14 female Wistar albino rats were divided into four groups; a female control, a male control, a female cisplatin and a male cisplatin group. Distortion Product Otoacoustic Emission and, Auditory Brainstem Response measurements were obtained. For the cisplatin groups 16 mg/kg of cisplatin was applied. On the 4th day audiological examinations were repeated. After killing, cochleae and brainstem tissues were evaluated by light and electron microscopy. The hearing of the female rat cisplatin group was found to have deteriorated more than the hearing of the male rat cisplatin group. Histopathological evaluation revealed more serious damage in the spiral ganglion and brainstem tissues of female rats. Hearing of female rats deteriorated more than the hearing of male rats upon application of cisplatin. This difference in hearing can be attributed to the more severe damage seen in neuronal tissues such as spiral ganglion cells and brainstem neurons.