Hypothalamic Nutrient Sensing and Energy Balance
Hypothalamic Nutrient Sensing and Energy Balance
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DOI：
10.1159/000264397
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发表时间：
2010-01-01
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影响因子：
--
通讯作者：
Moran, Timothy H.
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文献类型：
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作者：
Moran, Timothy H.
下丘脑神经元有能力感知并改变其活动，以响应局部营养物质浓度的波动。葡萄糖、脂肪酸和氨基酸浓度的改变都被证明会影响神经元的兴奋性和/或细胞内信号通路。养分可利用性的这种变化对能量平衡的影响程度因养分类型而异。各种营养物质影响食物摄入和整体能量平衡的潜在机制涉及特定和共享的神经元基质。版权所有：S. Karger AG，巴塞尔
Hypothalamic neurons have the capacity to sense and alter their activity in response to fluctuations in local nutrient concentrations. Alterations in glucose, fatty acid and amino acid concentrations have all been demonstrated to affect neuronal excitability and/or intracellular signaling pathways. The degree to which such changes in nutrient availability have the capacity to modify energy balance varies across nutrient type. The underlying mechanisms through which various nutrients affect food intake and overall energy balance involve both specific and shared neuronal substrates. Copyright (C) 2010 S. Karger AG, Basel