Current status of stem cell therapy in heart failure.
Current status of stem cell therapy in heart failure.
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DOI：
10.1007/s11886-010-0098-5
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发表时间：
2010-05
影响因子：
3.7
通讯作者：
Margulies, Kenneth B
中科院分区：
文献类型：
--
作者：
Codina, Marta;Elser, Jeremy;Margulies, Kenneth B
受成年哺乳动物心脏内新肌细胞形成潜力研究的启发，正在进行的研究爆炸正在阐明心肌发生和血管生成的生物学。多项研究表明，内源性心脏修复过程的疾病相关激活通常不足以克服心肌梗死和慢性心力衰竭导致的细胞死亡。在这种情况下，本文综述了目前的证据支持内源性心脏修复机制在人类心脏，心肌细胞治疗的临床应用的最新进展，并补充努力操纵内源性心肌修复过程中使用各种组织工程策略。本概述的目的是证明，从这些调查中的每一条线获得的见解和机会是相互补充的，最终实现治疗性心脏再生的目标。
Inspired by studies demonstrating the potential for new myocyte formation within adult mammalian hearts, an ongoing explosion of research is elucidating the biology of cardiac myogenesis and angiogenesis. Multiple lines of research suggest that disease-associated activation of endogenous cardiac repair processes are often insufficient to overcome the cell death resulting from myocardial infarction and chronic heart failure. In this context, this review highlights current evidence supporting endogenous cardiac repair mechanisms in human hearts, recent progress with clinical application of myocardial cell therapy, and complementary efforts to manipulate endogenous myocardial repair processes using a variety of tissue engineering strategies. The goal of this overview is to demonstrate that the insights and opportunities derived from each of these lines of inquiry are mutually complementary for ultimately achieving the goal of therapeutic cardiac regeneration.