Serum levels of KL-6 for predicting the occurrence of radiation pneumonitis after stereotactic radiotherapy for lung tumors
Serum levels of KL-6 for predicting the occurrence of radiation pneumonitis after stereotactic radiotherapy for lung tumors
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DOI：
10.1378/chest.125.1.340
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发表时间：
2004-01-01
期刊：
影响因子：
9.6
通讯作者：
Kondo, T
中科院分区：
文献类型：
--
作者：
Hara, R;Itami, J;Kondo, T
为了确定血清KL-6水平对预测肺肿瘤单次高剂量立体定向放疗后放射性肺炎（RP）发生的有用性，对16例患者在放疗前及放疗后每1、2个月测定血清KL-6水平。根据欧洲癌症研究和治疗组织/放射治疗肿瘤组毒性标准，16例患者中有3例经历了3级严重程度的RP。2例患者放疗结束3个月后发生RP， 1例患者放疗结束4个月后发生RP。原发性肺癌患者（p = 0.01）和腺癌患者（p = 0.01）以及同时接受伊立替康治疗的患者（p = 0.02）发生RP的频率显著增加。16例患者在随访期间乳酸脱氢酶水平均保持正常。在所有三名RP患者中，KL-6水平比治疗前增加了1.5倍，超过了500 IU的临界值。放疗后2个月血清kil6值的升高与R-P的发生有显著相关性（p = 0.04）。综上所述，KIL-6是预测肺肿瘤单次、分次、高剂量立体定向照射后RP发生的有效标志物。
To determine the usefulness of serum KL-6 levels for predicting the occurrence of radiation pneumonitis (RP) after the application of single high-dose stereotactic radiation therapy for lung tumors, the serum KL-6 levels were measured in 16 patients before irradiation and every 1 or 2 months thereafter. Three of the 16 patients experienced RP of grade 3 severity according to the European Organization for Research and Treatment of Cancer/Radiation Therapy Oncology Group toxicity criteria. RP occurred 3 months after the completion of radiation therapy in two patients, and 4 months after completion in one patient. RP occurred at significantly increased frequencies in patients with primary lung cancer (p = 0.01) and adenocarcinoma (p = 0.01), and in those undergoing the concurrent irinotecan therapy (p = 0.02). In all 16 patients, the lactate dehydrogenase level remained normal during the follow-up period. In all three of the patients with RP, KL-6 levels increased by > 1.5-fold compared to the pre-treatment value and over the cutoff level of 500 IU. The ratio of the increase in serum KIL-6 values 2 months after the patient had undergone irradiation showed a significant correlation with the occurrence of R-P (p = 0.04). In conclusion, KIL-6 is a useful marker for prediction of the occurrence of RP after single, fractional, high-dose stereotactic irradiation of lung tumors.