Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice.
Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice.
复制标题
造血和衰老。
DOI：
10.1080/03610738608259449
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发表时间：
1986
影响因子：
1.8
通讯作者：
Patrene,K
中科院分区：
文献类型：
--
作者：
Boggs,DR;Patrene,K
在 54、64、91、105 和 115 周龄的衰老 B6D2F 雌性小鼠中进行了血细胞比容的纵向研究。在 41/42 的小鼠中观察到血细胞比容适度下降；我们之前已经表明，与年轻小鼠相比，老年小鼠的血细胞比容降低是由于血浆容量的增加。 91周后自然死亡的小鼠在91周和105周时的血细胞比容低于存活至115周的小鼠。在每个时间间隔，杀死一组小鼠并研究血液、前腿、脾脏和肝脏中59 Fe的摄取并测定每个肱骨的有核细胞总数。结果总体上与衰老小鼠在基础条件下维持正常的冷细胞生成率的论点相一致。因此，血细胞比容的下降似乎可以被认为是该小鼠衰老过程的预期部分。
Longitudinal studies of hematocrits were done in aging B6D2F, female mice at 54, 64, 91, 105 and 115 weeks of age. A modest decline in hematocrit was observed in 41/42 mice; we have previously shown that the decreased hematocrit of aged as compared to young mice is due to an expansion of plasma volume. Mice which died spontaneously after 91 weeks had lower hematocrits at 91 weeks and 105 weeks than did those which survived to 115 weeks. At each time interval, a sub-group of mice was killed and uptake of59Fe into blood, foreleg, spleen and liver was studied and total nucleated cells per humerus was determined. The results were generally compatible with the thesis that aging mice maintain normal rates of crythropoiesis under basal conditions. Thus, it would appear that a decrease in hematocrit can be considered an expected part of the aging process in this mouse.