Sex-specific association of plasma nesfatin-1 concentrations with obesity in children
Sex-specific association of plasma nesfatin-1 concentrations with obesity in children
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DOI：
10.1111/ijpo.12567
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发表时间：
2019-09-10
影响因子：
3.8
通讯作者：
Garces, Carmen
中科院分区：
文献类型：
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作者：
de Dios, Olaya;Herrero, Leticia;Garces, Carmen
背景 Nesfatin-1 是一种抑制食欲的肽，与食物摄入和产热有关，但迄今为止在人类中的研究结果不一致，而在儿童中的研究却很少。目的 本研究的目的是分析两组儿童中肥胖与 nesfatin-1 水平的关系。方法 对 6 至 9 岁儿童 (n = 140) 和 12 至 16 岁儿童 (n = 96) 的血浆 nesfatin-1 浓度进行分析，其中包括肥胖儿童及其性别和年龄匹配的正常体重儿童。评估人体测量结果。通过酶法测定胆固醇和甘油三酯，使用商业试剂盒通过放射免疫测定法测量胰岛素浓度，并使用商业 ELISA 试剂盒测定 nesfatin-1、瘦素和 hs-CRP 浓度。结果 年轻 (P = .001) 和年长 (P = .009) 肥胖女孩的 Nesfatin-1 浓度显着低于体重正常的女孩，但男孩中没有表现出显着差异。 Nesfatin-1 在女孩中与体重和 BMI 呈显着负相关 (P < .010)，但在男孩中则不然。根据年龄和 BMI 进行调整后，女孩中的 nesfatin-1 水平与胰岛素、HOMA 和瘦素水平呈显着正相关。在年龄较大的儿童中，nesfatin-1 与脂肪量之间观察到显着的正相关性 (P = .003)。结论 我们的研究表明，在两个不同年龄段，nesfatin-1 浓度较低与女孩肥胖相关，但与男孩无关。 nesfatin-1 浓度与肥胖之间存在性别特异性关联，这突出表明需要按性别分析 nesfatin-1 与肥胖的关系。
Background Nesfatin-1, an anorexigenic peptide, has been associated with food intake and thermogenesis, with discordant findings in humans and scarce studies in children to date. Objectives The aim of this study was to analyze the relationship of obesity with nesfatin-1 levels in two cohorts of children. Methods Plasma nesfatin-1 concentrations were analyzed in 6- to 9-year-olds (n = 140) and 12- to 16-year-old children (n = 96), including children with obesity and their sex- and age-matched normal-weight counterparts. Anthropometric measurements were assessed. Cholesterol and triglycerides were determined enzymatically, insulin concentrations were measured by radioimmunoassay using a commercial kit and nesfatin-1, leptin and hs-CRP concentrations were determined using commercial ELISA kits. Results Nesfatin-1 concentrations were significantly lower in younger (P = .001) and older (P = .009) girls with obesity than in their normal-weight counterparts, without showing significant differences in boys. Nesfatin-1 showed a negative significant (P < .010) correlation with weight and BMI in girls but not in boys. A significant positive correlation of nesfatin-1 levels with insulin, HOMA, and leptin levels appears in girls after adjusting by age and BMI. A significant positive correlation (P = .003) was observed between nesfatin-1 and fat mass in older children. Conclusions Our study shows lower concentrations of nesfatin-1 related to obesity in girls but not in boys at two different ages. The existence of a sex-specific association between nesfatin-1 concentrations and presence of obesity highlights the need of an analysis by gender of the relationship of nesfatin-1 with obesity.