Risk-reducing salpingectomy: Let us be opportunistic.
Risk-reducing salpingectomy: Let us be opportunistic.
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DOI：
10.1002/cncr.30528
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发表时间：
2017-05-15
期刊：
影响因子：
6.2
通讯作者：
Zivanovic O
中科院分区：
文献类型：
--
作者：
Long Roche KC;Abu-Rustum NR;Nourmoussavi M;Zivanovic O
由于没有卵巢癌的筛查试验，有效的预防策略可能是降低这种最致命的妇科恶性肿瘤死亡率的最佳方法。越来越多的证据支持输卵管是绝大多数高级别浆液性癌的起源部位的假设。我们对这种疾病发病机制的了解不断加深，这为探索新的预防措施提供了难得的机会，例如双侧输卵管切除术，这可能会在不损害卵巢功能的情况下提供巨大的益处。如果输卵管范例是准确的，双侧输卵管切除术的影响可能会扩展到BRCA1和BRCA2突变携带者，高风险非携带者和平均风险的妇女。我们对所有女性和高危人群中输卵管切除术风险降低的作用进行了文献综述，重点关注发病率，卵巢功能，潜在的临床适用性和流行病学因素。
As there is no screening test for ovarian cancer, effective prevention strategies may be the best way to reduce the mortality of this most lethal gynecologic malignancy. Increasing evidence supports the hypothesis that the fallopian tube is the site of origin for the vast majority of high-grade serous carcinomas. Our growing understanding of the pathogenesis of this disease offers a rare opportunity to explore new preventive measures such as bilateral salpingectomy, which may provide great benefit without compromising ovarian function. If the tubal paradigm is accurate, the impact of bilateral salpingectomy could extend to BRCA1 and BRCA2 mutation carriers, high-risk non-carriers, and average-risk women. We present a review of the literature on the role of risk-reducing salpingectomy in all women and in high-risk groups, with a focus on morbidity, ovarian function, potential clinical applicability, and epidemiological considerations.