STEREOTAXIC HIGH-DOSE FRACTION RADIATION-THERAPY OF EXTRACRANIAL TUMORS USING AN ACCELERATOR - CLINICAL-EXPERIENCE OF THE FIRST 31 PATIENTS
STEREOTAXIC HIGH-DOSE FRACTION RADIATION-THERAPY OF EXTRACRANIAL TUMORS USING AN ACCELERATOR - CLINICAL-EXPERIENCE OF THE FIRST 31 PATIENTS
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DOI：
10.3109/02841869509127197
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发表时间：
1995-01-01
期刊：
影响因子：
3.1
通讯作者：
SVANSTROM, R
中科院分区：
文献类型：
--
作者：
BLOMGREN, H;LAX, I;SVANSTROM, R
已开发出一种带固定装置的立体定向体架，用于颅外靶点的立体定向放射治疗，这是一种与用于颅内靶点的立体定向头架类似的精确定位和定位系统。结果的前42个治疗肿瘤的31例。多为肝、肺或腹膜后间隙的孤立性肿瘤。临床靶体积范围为2至622 cm（3）（平均78 cm（3）），计划靶体积（PTV）的最小剂量为7.7-30戈伊/次平均14.2戈伊，分1-4次给药，PTV的最小总剂量为7.7 ~ 45戈伊PTV周围平均剂量30.2戈伊，PTV总平均剂量8-66戈伊，平均41戈伊。由于计划的不均匀剂量分布，肿瘤的中心部分通常比PTV的周边部分高出约50%的剂量。一些患者同时接受立体定向放射治疗多个靶点，另一些患者在随访期间也治疗了新的转移灶，在1.5-38个月的随访期内，我们观察到80%的局部无疾病进展率。50%的肿瘤缩小或消失。
A stereotactic body frame with a fixation device has been developed for stereotactic radiation therapy of extracranial targets, a precision localization and positioning system in analogy with the stereotactic head frames used for intracranial targets. Results of the first 42 treated tumors in 31 patients are presented. Most of the patients had solitary tumors in liver, lung or retroperitoneal space. Clinical target volumes ranged from 2 to 622 cm(3) (mean 78 cm(3)) and minimum doses to the planning target volumes (PTV) of 7.7-30 Gy/fraction (mean 14.2 Gy) were given on 1-4 occasions to a total minimum dose to the PTVs of 7.7-45 Gy (mean 30.2 Gy) to the periphery of the PTV and total mean doses to the PTVs of 8-66 Gy (mean 41 Gy). The central part of the tumor was usually given about 50% higher dose compared to that of the periphery of the PTV by a planned inhomogeneous dose distribution, Some of the patients received stereotactic radiation therapy concomitantly to more than one target, in others new metastases were also treated which appeared during the follow-up period, We observed a local rate of no progressive disease of 80% during a follow-up period of 1.5-38 months. Fifty percent of the tumors decreased in size or disappeared.