The Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular Regeneration.
The Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular Regeneration.
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DOI：
10.1155/2016/4389802
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发表时间：
2016
影响因子：
4.3
通讯作者：
Casado FL
中科院分区：
文献类型：
--
作者：
Casado FL
芳烃受体（AHR）在感知细胞环境的同时，与参与细胞内稳态的不同途径相互作用。这篇综述总结了证据表明，在衰老和疾病的背景下，细胞再生可以调节AHR信号对干细胞。新的见解将孤立的观察结果与AHR与关键信号通路（如WNT）的相互作用联系起来，提出这种配体激活的转录因子通过改变培养细胞扩增的通路（如代谢效率的变化）而不是直接改变细胞周期，增殖或细胞死亡来调节细胞再生的作用。靶向AHR以促进再生可能被证明是一种有用的策略，以避免可能促进疾病的体内平衡的不平衡破坏，并为潜在的再生医学方法提供生物学原理。
While sensing the cell environment, the aryl hydrocarbon receptor (AHR) interacts with different pathways involved in cellular homeostasis. This review summarizes evidence suggesting that cellular regeneration in the context of aging and diseases can be modulated by AHR signaling on stem cells. New insights connect orphaned observations into AHR interactions with critical signaling pathways such as WNT to propose a role of this ligand-activated transcription factor in the modulation of cellular regeneration by altering pathways that nurture cellular expansion such as changes in the metabolic efficiency rather than by directly altering cell cycling, proliferation, or cell death. Targeting the AHR to promote regeneration might prove to be a useful strategy to avoid unbalanced disruptions of homeostasis that may promote disease and also provide biological rationale for potential regenerative medicine approaches.