---Mechanosensitivity of aged muscle stem cells.
---Mechanosensitivity of aged muscle stem cells.
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DOI：
10.1002/jor.23797
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Jaspers RT
中科院分区：
文献类型：
--
作者：
Boers HE;Haroon M;Le Grand F;Bakker AD;Klein-Nulend J;Jaspers RT
在衰老过程中，骨骼肌组织的质量、强度和再生能力逐渐下降。肌肉干细胞（MuSC）数量减少和功能受损可能是衰老相关的肌肉萎缩和再生能力受损的基础。到目前为止，对调节MuSC命运和功能的因子的研究已经揭示了MuSC生态位内的几个生化因子，这些因子可能是导致MuSC再生能力下降的原因。这种下降不能仅仅用环境因素来解释，因为MuSC再生肌肉组织的潜力不能通过改变生化MuSC生态位组成来逆转。在这里，我们讨论了在体育锻炼期间，MuSC在其生态位内受到机械载荷，特别是压力和剪切应力以及相关变形的可能性。我们假设这些物理信号参与了MuSC的激活和分化，因为这些细胞含有几种跨膜传感器蛋白，这些蛋白已被证明在其他细胞类型（即内皮细胞和骨祖细胞）中具有机械敏感性。我们将专门讨论MuSC及其生态位中机械感知的年龄相关变化。深入了解体内MuSC的物理线索，以及这些线索如何影响MuSC的命运和功能，有助于开发新的治疗干预措施来平衡年龄相关的肌肉损失。这需要一种结合收缩肌肉组织内MuSC的二维和三维活细胞成像、数学有限元建模和细胞生物学的方法。版权所有© 2017作者. Journal of Orthopathy Research®由Wiley Periodicals，Inc.出版。我代表矫形外科研究协会J Orthop Res 36：632-641，2018.
During aging, skeletal muscle tissue progressively declines in mass, strength, and regenerative capacity. Decreased muscle stem cell (MuSC) number and impaired function might underlie the aging‐related muscle wasting and impaired regenerative capacity. As yet, the search for factors that regulate MuSC fate and function has revealed several biochemical factors within the MuSC niche that may be responsible for the decline in MuSC regenerative capacity. This decline cannot be explained by environmental factors solely, as the MuSC potential to regenerate muscle tissue is not reversed by changing the biochemical MuSC niche composition. Here we discuss the likeliness that during physical exercise, MuSCs within their niche are subjected to mechanical loads, in particular pressure and shear stress, as well as associated deformations. We postulate that these physical cues are involved in the activation and differentiation of MuSCs as these cells contain several transmembrane sensor proteins that have been shown to be mechanosensitive in other cell types, that is, endothelial cells and osteoprogenitors. We will specifically address age‐related changes in mechanosensing in MuSCs and their niche. Insight in the physical cues applied to the MuSCs in vivo, and how these cues affect MuSC fate and function, helps to develop new therapeutic interventions to counterbalance age‐related muscle loss. This requires an approach combining two‐ and three‐dimensional live cell imaging of MuSCs within contracting muscle tissue, mathematical finite element modeling, and cell biology. © 2017 The Authors. Journal of Orthopaedic Research® Published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 36:632–641, 2018.
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DOI：
10.1016/j.bbrc.2015.11.019
发表时间：
2015-12-25
影响因子：
3.1
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影响因子：
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82.9
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影响因子：
--
作者：
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通讯作者：
Huijing, PA