PREDICTORS OF INDIVIDUAL-DIFFERENCES IN ACUTE RESPONSE TO OZONE EXPOSURE
PREDICTORS OF INDIVIDUAL-DIFFERENCES IN ACUTE RESPONSE TO OZONE EXPOSURE
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DOI：
10.1164/ajrccm/147.4.818
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发表时间：
1993-04-01
期刊：
影响因子：
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通讯作者：
SHY, CM
中科院分区：
文献类型：
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作者：
MCDONNELL, WF;MULLER, KE;SHY, CM
本研究的目的是确定个人特征，以预测对臭氧暴露的急性 FEV1 反应的个体差异。收集了 290 名 18 至 32 岁白人男性志愿者的反应和预测数据，他们每人都暴露于百万分之 0.0 至 0.40 的六种臭氧浓度之一。样本分为96名受试者的探索性样本和194名受试者的验证性样本。探索性分析表明，臭氧、年龄和其他几个变量解释了响应方差的很大一部分。 在验证样本中，只有年龄和臭氧浓度预测 FEV1 下降。对于合并样本，臭氧解释了 31% 的差异，年龄则另外解释了 4%。该模型预测，随着年龄的增长，所有非零臭氧浓度的响应都会减弱。对于暴露于 0.40 ppm 的浓度，该模型预测 18 岁和 30 岁受试者的 FEV1 分别减少 1.07 和 0.47 L。我们得出的结论是，对于白人男性受试者来说，年龄是反应的重要预测因素，老年受试者对臭氧的反应较差。此外，我们证明，不控制 I 类统计错误率的探索性分析可能会导致无法复制的明显发现。
The purpose of this study was to identify personal characteristics that predict individual differences in acute FEV1 response to ozone exposure. Response and predictor data were collected on 290 white male volunteers 18 to 32 yr of age who were each exposed to one of six concentrations of ozone between 0.0 and 0.40 part per million. The sample was divided into an exploratory sample of 96 and a confirmatory sample of 194 subjects. Exploratory analysis indicated that ozone, age, and several other variables explained a significant proportion of the variance in response. In the confirmatory sample, only age and ozone concentration predicted FEV1 decrement. For the combined sample ozone explained 31% of the variance, with age accounting for an additional 4%. The model predicted a decreasing response with increasing age for all nonzero ozone concentrations. For exposure to 0.40 ppm, the model predicts decrements in FEV1 of 1.07 and 0.47 L for 18- and 30-yr-old subjects, respectively. We concluded that for white male subjects age was a significant predictor of response, with older subjects being less responsive to ozone. Furthermore, we demonstrated that exploratory analysis without control of type I statistical error rates may result in apparent findings that cannot be replicated.