Visceral nociceptive input into the ventral posterolateral nucleus of the thalamus: A new function for the dorsal column pathway
Visceral nociceptive input into the ventral posterolateral nucleus of the thalamus: A new function for the dorsal column pathway
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DOI：
10.1152/jn.1996.76.4.2661
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发表时间：
1996-10-01
影响因子：
2.5
通讯作者：
Willis, WD
中科院分区：
文献类型：
--
作者：
AlChaer, ED;Lawand, NB;Willis, WD
1.在麻醉雄性大鼠丘脑腹后外侧核（VPL）的单个神经元进行细胞外记录。在依次损伤背柱（DC）和腹外侧柱（VLC）之前和之后，进一步用皮肤和内脏刺激测试对结肠直肠扩张（CRD）有反应的VPL细胞。共分离出105个VPL内脏敏感细胞。在这项研究中，我们报告了27个细胞的结果，这些细胞在DC和VLC病变前后进行了内脏反应测试。10个VPL细胞，分离在10个不同的大鼠，响应CRD和激活他们的皮肤感受野与无害和有害的刺激进行了测试之前和之后的DC的病变，并再次后的VLC的病变。在10只不同的大鼠中分离出10个其他VPL细胞。这些也进行了测试的反应CRD和皮肤刺激跨越无害和有害的范围之前和之后的VLC病变和再次病变后的DC。4. DC的损伤显著降低了VPL细胞对CRD以及无害的皮肤刺激的反应。VLC的损伤减少，有时取消VPL细胞对伤害性皮肤刺激的反应;然而，与DC损伤相比，其对内脏或无害皮肤刺激的反应的影响较小。7 VPL细胞的活性，CRD和皮肤刺激后，观察到的化学刺激剂，芥子油（MO），注入结肠。这些细胞显示出背景活性的增加，其开始类似于MO注射后25-30分钟。DC的损伤将细胞的背景活性降低到接近初始值的水平。我们的结论是，在大鼠的DC中包含一个更重要的途径，用于传输内脏伤害性信号的VPL核比VLC中的途径，包括脊髓丘脑束。相反，VLC对于传递皮肤源的伤害性信息更重要。
1. Extracellular recordings were made from single neurons in the ventral posterolateral (VPL) nucleus of the thalamus in anesthetized male rats. VPL cells that responded to colorectal distension (CRD) were further tested with cutaneous and visceral stimuli before and after sequential lesions of the dorsal column (DC) and of the ventrolateral column (VLC).2. A total of 105 VPL viscerosensitive cells was isolated. In this study, we report results from 27 cells that were tested for visceral responses before and after lesions of the DC and the VLC.3. Ten VPL cells, isolated in 10 different rats, that responded to CRD and to activation of their cutaneous receptive fields with innocuous and noxious stimuli were tested before and after a lesion of the DC and again after a lesion of the VLC. Ten other VPL cells were isolated in 10 different rats. These were also tested for responses to CRD and to cutaneous stimuli spanning the innocuous and the noxious range before and after a lesion of the VLC and again after a lesion of the DC.4. A lesion of the DC dramatically reduced the responses of VPL cells to CRD as well as to innocuous cutaneous stimuli. A lesion of the VLC reduced and sometimes abolished the responses of VPL cells to noxious cutaneous stimuli; however, its effect on the responses to visceral or innocuous cutaneous stimuli was minor when compared with that of a DC lesion.5. The activity of seven VPL cells that responded to CRD and to cutaneous stimuli was observed after an injection of a chemical irritant, mustard oil (MO), into the colon. These cells showed an increase in background activity that started similar to 25-30 min after the MO injection. A lesion of the DC reduced the background activity of the cells to levels near initial values.6. We conclude that the DC in the rat contains a pathway that is more important for transmitting visceral nociceptive signals to the VPL nucleus than are pathways in the VLC, including the spinothalamic tract. Conversely, the VLC is more important for transmitting nociceptive information of cutaneous origin.