Strategies on biosynthesis and production of bioactive compounds in medicinal plants
Strategies on biosynthesis and production of bioactive compounds in medicinal plants
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DOI：
10.1016/j.chmed.2023.01.007
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发表时间：
2023-08
影响因子：
3.8
通讯作者：
Miaoxian Guo;Hai-zhou Lv;Hongyu Chen;Shuting Dong;Jianhong Zhang;Wanjing Liu;Liu He;Yimian Ma-Yim
中科院分区：
文献类型：
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作者：
Miaoxian Guo;Hai-zhou Lv;Hongyu Chen;Shuting Dong;Jianhong Zhang;Wanjing Liu;Liu He;Yimian Ma-Yim
药用植物是用于保健和疾病治疗的基本药物和草药产品的宝贵来源。与化学合成和提取相比，天然产物的生物合成是成功保护药用植物的一个非常有前途的选择，它的迅速发展将大大促进药用植物的保护和可持续利用。本文综述了药用植物天然产物生物合成及生产的策略和方法。其策略和方法主要包括基因工程、植物细胞培养工程、代谢工程和基于多个“OMICS”技术的合成生物学，并以萜类和生物碱的生物合成为范例。我们还强调了生物合成的方法，并讨论了一些有价值的天然产物的生产进展，举例说明化合物，如文多灵（生物碱），青蒿素和紫杉醇（萜类化合物），以说明生物技术在药用植物中的力量。
Medicinal plants are a valuable source of essential medicines and herbal products for healthcare and disease therapy. Compared with chemical synthesis and extraction, the biosynthesis of natural products is a very promising alternative for the successful conservation of medicinal plants, and its rapid development will greatly facilitate the conservation and sustainable utilization of medicinal plants. Here, we summarize the advances in strategies and methods concerning the biosynthesis and production of natural products of medicinal plants. The strategies and methods mainly include genetic engineering, plant cell culture engineering, metabolic engineering, and synthetic biology based on multiple “OMICS” technologies, with paradigms for the biosynthesis of terpenoids and alkaloids. We also highlight the biosynthetic approaches and discuss progress in the production of some valuable natural products, exemplifying compounds such as vindoline (alkaloid), artemisinin and paclitaxel (terpenoids), to illustrate the power of biotechnology in medicinal plants.