Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells
Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells
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DOI：
10.1016/j.molimm.2004.07.033
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发表时间：
2005-02-01
影响因子：
3.6
通讯作者：
Ljunggren, HG
中科院分区：
文献类型：
--
作者：
Screpanti, V;Wallin, RPA;Ljunggren, HG
NK细胞的细胞毒性效应子功能对于使免疫系统能够有效地科普感染和恶性肿瘤是重要的。细胞毒性的两种主要机制是穿孔素/颗粒酶介导的和死亡受体介导的（例如，FASL-或TRAIL-介导的）诱导细胞死亡。许多研究，包括在穿孔素缺陷动物中的研究，已经得出结论，穿孔素/颗粒酶介导的细胞死亡诱导是NK细胞用于消除病毒感染或转化细胞的主要途径。然而，死亡受体介导的细胞凋亡也可能有助于NK细胞介导的细胞毒性，如最近的报道所揭示的。在本文中，我们回顾了目前的数据，死亡受体介导的肿瘤细胞凋亡的NK细胞，特别强调的作用，NK细胞FASL的RMA/RMA-S肿瘤模型。(C)2004爱思唯尔有限公司保留所有权利。
The cytotoxic effector functions of NK cells are important for enabling the immune system to cope efficiently with infection and malignancy. Two major mechanisms of cytotoxicity are perforin/granzyme- and death receptor-mediated (e.g., FASL- or TRAIL-mediated) induction of cell death. Many studies, including studies in perforin-deficient animals, have led to the conclusion that perforin/granzyme-mediated induction of cell death is a principal pathway used by NK cells to eliminate virus-infected or transformed cells. However, death receptor-mediated apoptosis may also contribute to NK cell-mediated cytotoxicity, as revealed by more recent reports. In the present paper, we have reviewed current data on death receptor-mediated tumor cell apoptosis by NK cells with a particular emphasis on the role of NK cell FASL in the RMA/RMA-S tumor model. (C) 2004 Elsevier Ltd. All rights reserved.