Sleep/wake firing patterns of human genioglossus motor units
Sleep/wake firing patterns of human genioglossus motor units
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DOI：
10.1152/jn.00865.2007
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发表时间：
2007-12-01
影响因子：
2.5
通讯作者：
Rice, Amber D.
中科院分区：
文献类型：
--
作者：
Bailey, E. Fiona;Fridel, Keith W.;Rice, Amber D.
人类颏舌肌运动单位的睡眠/觉醒放电模式。神经生理学杂志98：3284-3291，2007。首次发表于2007年10月10日; doi：10.1152/jn.00865.2007。尽管对主要舌肌或颏舌肌（GG）的研究表明，整个肌GG肌电图（EMG）活动在非快速眼动（NREM）睡眠中得以保留，但尚不清楚睡眠对个体GG运动单位（MU）活动的影响。我们表征了人类GG MU在觉醒和NREM睡眠中的放电模式，目的是确定1）在觉醒中明显的MU放电模式的范围是否在睡眠中保留，以及2）去除“觉醒”输入对MU活动的呼吸调节的幅度有什么影响。微电极插入到外源性舌肌，颏舌肌，被用来跟踪放电的单个MU。我们分类MU活动的基础上的尖峰序列和呼吸周期之间的时间关系，并量化的幅度呼吸调制的每一个MU使用eta（eta（2））指数，在清醒和睡眠。大多数MU在呼吸调节方面表现出微妙的增加或减少，但不受NREM睡眠的影响。相反，30%的MU在放电频率和呼吸调节方面表现出明显的睡眠相关变化。我们认为，GG MU不应该被认为是完全紧张或阶段性的，相反，放电模式似乎是一个灵活的功能，GG活动在健康的年轻人。这种灵活性是否是重要的化学和/或机械环境的变化，以及它是否被保存为一个功能的老化或阻塞性睡眠呼吸暂停的个人是未来研究的关键问题。
Sleep/wake firing patterns of human genioglossus motor units. J Neurophysiol 98: 3284-3291, 2007. First published October 10, 2007; doi:10.1152/jn.00865.2007. Although studies of the principal tongue protrudor muscle genioglossus (GG) suggest that whole muscle GG electromyographic (EMG) activities are preserved in nonrapid eye movement (NREM) sleep, it is unclear what influence sleep exerts on individual GG motor unit (MU) activities. We characterized the firing patterns of human GG MUs in wakefulness and NREM sleep with the aim of determining 1) whether the range of MU discharge patterns evident in wakefulness is preserved in sleep and 2) what effect the removal of the "wakefulness" input has on the magnitude of the respiratory modulation of MU activities. Microelectrodes inserted into the extrinsic tongue protrudor muscle, the genioglossus, were used to follow the discharge of single MUs. We categorized MU activities on the basis of the temporal relationship between the spike train and the respiration cycle and quantified the magnitude of the respiratory modulation of each MU using the eta (eta(2)) index, in wakefulness and sleep. The majority of MUs exhibited subtle increases or decreases in respiratory modulation but were otherwise unaffected by NREM sleep. In contrast, 30% of MUs exhibited marked sleep-associated changes in discharge frequency and respiratory modulation. We suggest that GG MUs should not be considered exclusively tonic or phasic; rather, the discharge pattern appears to be a flexible feature of GG activities in healthy young adults. Whether such flexibility is important in the response to changes in the chemical and/or mechanical environment and whether it is preserved as a function of aging or in individuals with obstructive sleep apnea are critical questions for future research.