Diverticular fistulation is associated with nicorandil usage
Diverticular fistulation is associated with nicorandil usage
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DOI：
10.1308/003588410x12699663904673
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发表时间：
2010-09-01
影响因子：
1.4
通讯作者：
Savage, Adrian P.
中科院分区：
文献类型：
--
作者：
McDaid, James;Reichl, Claire;Savage, Adrian P.
引言我们观察到，一些到我们诊所就诊的憩室瘘患者服用尼可地尔治疗心绞痛。尼可地尔的公认副作用包括胃肠道和生殖器溃疡。我们研究的目的是确定尼可地尔是否是憩室fistulation.Patients和方法的病因，我们进行了一项病例对照研究憩室疾病相关的肠瘘患者。确定了两个患者组：憩室瘘患者的研究组和单纯憩室疾病的对照组。比较两组间曾使用尼可地尔的患者比例。结果共分析了153例病例记录，69例瘘管患者和84例对照组单纯憩室病患者。两组的女性与男性比例为2：1。瘘管组的平均年龄为71岁，对照憩室病组的平均年龄为69岁（P = ns）。在结肠瘘患者中，16%服用尼可地尔，而对照组为2%（比值比7.8; 95%置信区间1.5-39.1; P = 0.008）。瘘和对照组之间缺血性心脏病的发病率无显著差异。结论尼可地尔与憩室病瘘的形成有关。
INTRODUCTION We observed that a number of patients presenting to our clinic with diverticular fistulation were taking nicorandil for angina. Recognised side effects of nicorandil include gastrointestinal and genital ulceration. The aim of our study was to determine whether nicorandil is an aetiological agent in diverticular fistulation.PATIENTS AND METHODS We conducted a case-control study of patients with diverticular disease related enteric fistulae. Two patient groups were identified: a study group of patients with diverticular fistulae, and a control group with uncomplicated diverticular disease. The proportion of patients who had ever used nicorandil was compared between the two groups.RESULTS A total of 153 case notes were analysed, 69 patients with fistulae and 84 control patients with uncomplicated diverticular disease. Female to male ratio in both groups was 2:1. The mean age was 71 years in the fistula group and 69 years in the control diverticular disease group (P = ns). Of those with colonic fistulae, 16% were taking nicorandil compared with 2% of the control group (odds ratio 7.8; 95% confidence interval 1.5-39.1; P = 0.008). There was no significant difference in rates of ischaemic heart disease between fistula and control groups.CONCLUSIONS Nicorandil is associated with fistula formation in diverticular disease.