FGF-2 - APICAL ECTODERMAL RIDGE GROWTH SIGNAL FOR CHICK LIMB DEVELOPMENT
FGF-2 - APICAL ECTODERMAL RIDGE GROWTH SIGNAL FOR CHICK LIMB DEVELOPMENT
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DOI：
10.1126/science.7908145
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发表时间：
1994-04-01
期刊：
影响因子：
56.9
通讯作者：
SIMANDL, BK
中科院分区：
文献类型：
--
作者：
FALLON, JF;LOPEZ, A;SIMANDL, BK
顶端外胚层脊允许生长和延长的肢芽;去除引起中胚层基因表达的快速变化，模式化的细胞死亡，和截断的肢体。在嵴去除后，向鸡顶芽中胚层提供异位成纤维细胞生长因子（FGF）-2将维持正常的基因表达和细胞活力，并允许相对正常的肢体发育。FGF的生物测定表明，FGF-2是鸡肢芽提取物中唯一可检测到的FGF。通过分布和生物活性，FGF-2是鸡肢芽顶嵴生长信号的主要候选者。
The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene expression, patterned cell death, and truncation of the limb. Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development. A bioassay for FGFs demonstrated that FGF-2 was the only detectable FGF in chick limb bud extracts. By distribution and bioactivity, FGF-2 is the prime candidate for the chick limb bud apical ridge growth signal.