Interactive effects of morphine and dopamine receptor agonists on spatial recognition memory in mice
Interactive effects of morphine and dopamine receptor agonists on spatial recognition memory in mice
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吗啡和多巴胺受体激动剂对小鼠空间识别记忆的相互作用
DOI：
10.1111/1440-1681.12889
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发表时间：
2018
影响因子：
2.9
通讯作者：
Zhang Jichuan
中科院分区：
文献类型：
--
作者：
Chen Yanmei;Fu Yu;An Yingjie;Cao Jun;Wang Jianhong;Zhang Jichuan
阿片类药物和多巴胺在学习和记忆中起重要作用。虽然这两种神经递质之间的协同作用已被发现，其功能作用仍不清楚。在此，在两次识别Y迷宫中的记忆测试之前30分钟，将对空间识别记忆没有影响的低剂量吗啡（2.5 mg/kg）和低剂量多巴胺受体激动剂（阿扑吗啡0.05 mg/kg; SKF 38393 0.01 mg/kg;溴隐亭0.05 mg/kg）腹膜内注射到小鼠中。Y迷宫是基于啮齿动物探索新环境的先天倾向，因此适合探索吗啡对学习和记忆的影响。我们的研究结果表明，D1样和D2样多巴胺受体激动剂均剂量依赖性地损害Y迷宫中空间识别记忆的提取，并且联合给予记忆无效剂量的阿扑吗啡（0.05 mg/kg）、SKF 38393（0.01 mg/kg）或溴隐亭（0.05 mg/kg）和吗啡（2.5 mg/kg）导致小鼠空间识别记忆提取受损。这些发现表明吗啡和多巴胺受体激动剂在记忆过程中存在相互作用，多巴胺系统的激活可能有助于吗啡诱导的记忆障碍，这可能为人类成瘾提供见解。
Both opiates and dopamine play important roles in learning and memory. Although synergistic action between these two neurotransmitters has been found, their functional roles remain unclear. Here, low dose morphine (2.5 mg/kg) and low dose dopamine receptor agonists (apomorphine 0.05 mg/kg; SKF38393 0.01 mg/kg; bromocriptine 0.05 mg/kg), which have no effects on spatial recognition memory, were injected intraperitoneally into mice 30 minutes before a memory test in a two‐trial recognition Y‐maze. The Y‐maze is based on the innate tendency of rodents to explore novel environments and is therefore suitable for exploring the effects of morphine on learning and memory. Our results showed that both D1‐like and D2‐like dopamine receptor agonists dose‐dependently impaired the retrieval of spatial recognition memory in the Y‐maze, and co‐administration of memory ineffective doses of apomorphine (0.05 mg/kg), SKF38393 (0.01 mg/kg), or bromocriptine (0.05 mg/kg) and of morphine (2.5 mg/kg) resulted in impaired spatial recognition memory retrieval in mice. These findings suggest the existence of interactions between morphine and dopamine receptor agonists in memory processing and that activation of the dopamine system might contribute to morphine‐induced impairment of memory, which could provide insight into human addiction.