Linking syndromic surveillance with virological self-sampling
Linking syndromic surveillance with virological self-sampling
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DOI：
10.1017/s0950268807008412
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发表时间：
2008-02-01
影响因子：
4.2
通讯作者：
Zambon, M.
中科院分区：
文献类型：
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作者：
Cooper, D. L.;Smith, G. E.;Zambon, M.
拨打英国国家电话健康热线(NHS Direct)的电话已被用于综合症监测，旨在为社区发病率上升提供早期警告。我们调查了NHS直拨电话的自我采样是否可以为流感培养提供可行的样本。我们招募了294名NHS直拨电话的人，并向他们发送了自我采样工具包。打电话的人被要求从每个鼻孔取一根棉签，然后寄到实验室。42%的样本被退回，16.2%的样本对流感(16例甲型H3N1流感、3例甲型H1N1流感、4例乙型流感)和8例呼吸道合胞病毒(5.6%)呈阳性反应。NHS直拨电话和实验室分析之间的平均时间为7.4天。这些样本提供了本季最早的流感报告之一，检测到多种流感毒株，并加强了国家综合征监测系统。自我抽样是加强以社区为基础的流感监测方案的可行方法。
Calls to a UK national telephone health helpline (NHS Direct) have been used for syndromic surveillance, aiming to provide early warning of rises in community morbidity. We investigated whether self-sampling by NHS Direct callers could provide viable samples for influenza culture. We recruited 294 NHS Direct callers and sent them self-sampling kits. Callers were asked to take a swab from each nostril and post them to the laboratory. Forty-two per cent of the samples were returned, 16.2 % were positive on PCR for influenza (16 influenza A(H3N2), three influenza A (H1N1), four influenza B) and eight for RSV (5.6%). The mean time between the NHS Direct call and laboratory analysis was 7.4 days. These samples provided amongst the earliest influenza reports of the season, detected multiple influenza strains, and augmented a national syndromic surveillance system. Self-sampling is a feasible method of enhancing community-based surveillance programmes for detection of influenza.