Chronic stress affects PERIOD2 expression through glycogen synthase kinase-3β phosphorylation in the central clock
Chronic stress affects PERIOD2 expression through glycogen synthase kinase-3β phosphorylation in the central clock
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DOI：
10.1097/wnr.0b013e32834e7ec2
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发表时间：
2012-01-25
期刊：
影响因子：
1.7
通讯作者：
Ishida, Norio
中科院分区：
文献类型：
--
作者：
Kinoshita, Chisato;Miyazaki, Koyomi;Ishida, Norio
情绪障碍被认为与昼夜节律的改变有关，但它们之间的相关性仍然不清楚。情绪稳定剂锂是糖原合成酶激酶-3 β（GSK-3 β）的抑制剂，GSK-3 β是生物钟系统的调节剂。在这里，我们表明，慢性约束（CR）的压力减少了小鼠的行为活动和节奏。CR应激升高了GSK-3 β磷酸化，并减弱了大脑中PERIOD 2（PER 2）的节律性表达。此外，锂，当给予施加压力的小鼠，减少GSK-3 β磷酸化和恢复PER 2表达在视交叉上核在夜间特异性的方式。这些数据表明，CR应激通过改变视交叉上核中PER 2和GSK-3 β磷酸化的昼夜基因表达来改变昼夜行为节律。NeuroReport 23：98-102（C）2012威科健康|利平科特·威廉姆斯和威尔金斯。
Mood disorders are considered to be associated with altered circadian rhythms, but the correlation between them has remained obscure. The mood stabilizer, lithium, is an inhibitor of glycogen synthase kinase-3 beta (GSK-3 beta), which is a modulator of the circadian clock system. Here, we show that chronic restraint (CR) stress diminishes behavioral activity and rhythmicity in mice. CR stress elevated GSK-3 beta phosphorylation and blunted the rhythmic expression of PERIOD2 (PER2) in the brain. Moreover, lithium, when administered to the stress-imposed mice, reduced GSK-3 beta phosphorylation and restored PER2 expression in the suprachiasmatic nucleus in a nighttime-specific manner. These data suggest that CR stress altered the circadian behavioral rhythm through a change in circadian gene expression of PER2 and GSK-3 beta phosphorylation in the suprachiasmatic nucleus. NeuroReport 23: 98-102 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.