Nanonization of poorly water-soluble drug clobetasone butyrate by using femtosecond laser
Nanonization of poorly water-soluble drug clobetasone butyrate by using femtosecond laser
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DOI：
10.1016/j.optcom.2013.10.035
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发表时间：
2014-02
影响因子：
2.4
通讯作者：
Sunqiang Pan;G. Takebe;Masumi Suzuki;Hisayoshi Takamoto;J. Ge;Chong Liu;M. Hiramatsu
中科院分区：
文献类型：
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作者：
Sunqiang Pan;G. Takebe;Masumi Suzuki;Hisayoshi Takamoto;J. Ge;Chong Liu;M. Hiramatsu
药物纳米化是一种提高难溶性药物溶出度和生物利用度的有效方法。使用脉冲宽度可调谐的飞秒激光器以泊洛沙姆188作为稳定剂来制备丁酸氯倍他松纳米粒。首次研究了温度和脉宽对颗粒粒径和浓度的影响。研究了粒径和药物浓度对激光强度和照射时间的依赖性。渗透性实验表明激光纳米化可提高药物透过Caco-2细胞单层的能力。这种激光纳米化方法具有很大的潜力，可用于新药开发。
Nanonization, which involves the formation of the drug with nanometer particle size, is an effective method to improve the dissolution rate and bioavailability of poorly water-soluble drugs. A pulsewidth-tunable femtosecond laser was used to produce nanoparticles of clobetasone butyrate using poloxamer 188 as stabilizing agent. The effects of temperature and pulsewidth on the particle size and concentration were studied for the first time. The particle size and drug concentration dependence on the laser intensity and irradiation time were also investigated. Permeability test releaved that laser nanonization improved the drug permeability across Caco-2 cell monolayer. This laser nanonization method has a great potential to be used for new drug development.