DEVELOPMENTAL NEUROBIOLOGY OF SALT TASTE SENSATION
DEVELOPMENTAL NEUROBIOLOGY OF SALT TASTE SENSATION
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DOI：
10.1016/0166-2236(90)90046-d
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发表时间：
1990-05-01
影响因子：
15.9
通讯作者：
MISTRETTA, CM
中科院分区：
文献类型：
--
作者：
HILL, DL;MISTRETTA, CM
钠水平的稳态控制的一个主要过程是盐的摄入，味觉在调节摄入方面起主要作用。由于氯化钠（NaCl）的摄入是生命所必需的，盐感觉的味觉系统可能会在非常早期的发育中表现出成熟的功能特征。然而，主要的变化，味觉神经反应的氯化钠我发生在发展过程中。在绵羊和大鼠中，周围神经对NaCl的反应在早期发育期间是低幅度的。逐渐地，味觉系统获得对NaCl最大响应的纤维的比例增加。钠反应性出现的背景下，外周神经支配模式的变化和明显增加的功能性受体膜通道敏感的钠转运阻滞剂，阿米洛利。这些发育过程可以通过早期控制饮食中的钠来改变，盐的摄入是维持电解质（钠）适当细胞外浓度的一系列调节机制中至关重要的第一步。在检测、识别和摄取NaCl中起作用的主要感觉系统是味觉。由于钠的摄入对于生命是必不可少的，因此可以假设钠味觉的受体机制发展和成熟较早，并且对环境操纵保持抵抗力。相反，钠味觉系统在发育过程中逐渐成熟，至少在早期阶段，易受环境变化的影响。在这篇综述中，我们描述了哺乳动物发育过程中发生的系统的，深刻的变化-
A principalprocess in the homeostatic control of sodium levels is salt intake, and the sense of taste has a primary role in regulating ingestion. Because ingestion of sodium chloride (NaCI) is essential for life, the taste system for salt sensation might be expected to exhibit mature functional characteristics from very early development. However, major changes in gustatory nerve responses to NaC I take place during development. In sheep and rat, the peripheral nerve responses to NaCI are of low magnitude during early development. Progressively, the taste system acquires an increasing proportion of fibers that respond maximally to NaCI. The sodium responsiveness emerges in the context of shifting peripheral innervation patterns and the apparent addition of functional receptor membrane channels sensitive to the sodium transport blocker, amiloride. These developmental processes can be altered by early manipulation of sodium in the diet.Ingestion of salt is a crucial first step in the series of regulatory mechanisms that maintain appropriate extracellular concentrations of the electrolyte, sodium. The primary sensory system that operates in detection, recognition and ingestion of NaC1 is taste. Because ingestion of sodium is essential for life, it might be assumed that receptor mechanisms for sodium taste develop and mature early, and remain resistant to environmental manipulation. On the contrary, the sodium taste system matures gradually during development and, at least in early stages, is susceptible to environmental alterations. In this review, we describe systematic, profound changes that take place during mammalian develop-